| Gene Symbol |
PTGIS
|
| Entrez Gene |
5740
|
| Alt Symbol |
CYP8, CYP8A1, PGIS, PTGI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin I2 (prostacyclin) synthase
|
| Other Description |
cytochrome P450, family 8, subfamily A, polypeptide 1|prostacyclin synthase|prostaglandin I2 synthase
|
| Swissprots |
Q3MII8 Q9HAX3 Q9HAX4 Q16647 Q9HAX2
|
| Accessions |
BAA11910 BAA28219 CCQ43002 EAW75655 Q16647 AF297048 AAG31781 AF297049 AAG31782 AF297050 AAG31783 AF297051 AAG31784 AF297052 AAG31785 AK055640 BC101809 AAI01810 BC101811 AAI01812 BC143381 D38145 BAA07343 NM_000961 NP_000952
|
| Function |
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
|
| Top Pathways |
Arachidonic acid metabolism
|