Gene Symbol | PTGIS |
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Entrez Gene | 5740 |
Alt Symbol | CYP8, CYP8A1, PGIS, PTGI |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin I2 (prostacyclin) synthase |
Other Description | cytochrome P450, family 8, subfamily A, polypeptide 1|prostacyclin synthase|prostaglandin I2 synthase |
Swissprots | Q3MII8 Q9HAX3 Q9HAX4 Q16647 Q9HAX2 |
Accessions | BAA11910 BAA28219 CCQ43002 EAW75655 Q16647 AF297048 AAG31781 AF297049 AAG31782 AF297050 AAG31783 AF297051 AAG31784 AF297052 AAG31785 AK055640 BC101809 AAI01810 BC101811 AAI01812 BC143381 D38145 BAA07343 NM_000961 NP_000952 |
Function | Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. |
Tissue Specificity | Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate. |
Top Pathways | Arachidonic acid metabolism |
PGI2 synthase CRISPR/Cas9 KO Plasmid (h) - sc-403180 from Santa Cruz Biotechnology
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PGI2 synthase HDR Plasmid (h) - sc-403180-HDR from Santa Cruz Biotechnology
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PGI2 synthase Double Nickase Plasmid (h) - sc-403180-NIC from Santa Cruz Biotechnology
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PGI2 synthase Double Nickase Plasmid (h2) - sc-403180-NIC-2 from Santa Cruz Biotechnology
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PGI2 synthase CRISPR Activation Plasmid (h) - sc-403180-ACT from Santa Cruz Biotechnology
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PGI2 synthase CRISPR Activation Plasmid (h2) - sc-403180-ACT-2 from Santa Cruz Biotechnology
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PGI2 synthase Lentiviral Activation Particles (h) - sc-403180-LAC from Santa Cruz Biotechnology
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PGI2 synthase Lentiviral Activation Particles (h2) - sc-403180-LAC-2 from Santa Cruz Biotechnology
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PGI2 synthase siRNA (h) - sc-37236 from Santa Cruz Biotechnology
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PGI2 synthase shRNA Plasmid (h) - sc-37236-SH from Santa Cruz Biotechnology
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PGI2 synthase shRNA (h) Lentiviral Particles - sc-37236-V from Santa Cruz Biotechnology
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Prostaglandin I2 Synthase RNAi - H00005740-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1851 from Sigma-Aldrich
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PTGIS siRNA (Human) - CRH3882 from Cohesion Biosciences
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shRNA set against Human PTGIS (NM_000961.3) - SHH386100 from Creative biogene
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shRNA set against Human PTGIS(NM_000961.3) - SHR107034 from Creative biogene
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Human PTGIS siRNA - orb264384 from Biorbyt
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PTGIS shRNA Plasmid (Human) - CHH3882 from Cohesion Biosciences
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PTGIS miRNA 3'UTR clone - MiUTR1H-08427 from Creative biogene
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