PTGIS

Gene Symbol PTGIS
Entrez Gene 5740
Alt Symbol CYP8, CYP8A1, PGIS, PTGI
Species Human
Gene Type protein-coding
Description prostaglandin I2 (prostacyclin) synthase
Other Description cytochrome P450, family 8, subfamily A, polypeptide 1|prostacyclin synthase|prostaglandin I2 synthase
Swissprots Q3MII8 Q9HAX3 Q9HAX4 Q16647 Q9HAX2
Accessions BAA11910 BAA28219 CCQ43002 EAW75655 Q16647 AF297048 AAG31781 AF297049 AAG31782 AF297050 AAG31783 AF297051 AAG31784 AF297052 AAG31785 AK055640 BC101809 AAI01810 BC101811 AAI01812 BC143381 D38145 BAA07343 NM_000961 NP_000952
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Top Pathways Arachidonic acid metabolism

PGI2 synthase (H-250) - sc-20933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PGI2 synthase (H-250): sc-20933. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urothelial cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PGI2 synthase (D-17) - sc-31077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PTGIS antibody - ab72952 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PTGIS antibody (ab72952) at 1/500 dilutionLane 1 : PTGIS transfected 293T cell line Lane 2 : non transfected 293T cell line Lysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-PTGIS antibody - N-terminal - ab79846 from Abcam

Prices $313.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PTGIS antibody - N-terminal (ab79846) at 1/50 dilution + Mouse lung tissue lysate at 35 µg

Anti-PGIS / PTGIS Antibody (clone isn-1) - LS-C11192 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ea
Host Mouse
Clonality Monoclonal
Clone isn-1

Anti-PGIS / PTGIS Antibody (aa30-61) - LS-C99809 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CYP8A1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PGIS / PTGIS Antibody (aa396-445) - LS-C110940 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTGIS antibody LS-C110940 Western blot of Fetal Brain lysate.

Anti-PGIS / PTGIS Antibody (aa472-500) - LS-C167246 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with CYP8A1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PGIS / PTGIS Antibody (clone 3B11) - LS-C198028 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B11
Western Blot analysis of PTGIS expression in transfected 293T cell line by PTGIS monoclonal antibody (M02), clone 3B11.Lane 1: PTGIS transfected lysate (Predicted MW: 57.1 KDa).Lane 2: Non-transfected lysate.

Anti-PGIS / PTGIS Antibody (aa475-490) IHC-plus™ - LS-B1505 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-PTGIS antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1505 concentration 20 ug/ml.

Anti-PGIS / PTGIS Antibody (aa299-329) IHC-plus™ - LS-B1615 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-PTGIS antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1615 concentration 5 ug/ml.

Anti-PGIS / PTGIS Antibody (aa475-490) IHC-plus™ - LS-B2436 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PTGIS antibody IHC of human lung, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2436 concentration 5 ug/ml.

Prostaglandin I2 Synthase Antibody (852307) [Unconjugated] - MAB7788 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 852307
Western blot shows lysates of SK‑OV‑3 human ovarian adenocarcinoma cell line and human ovary tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human Prostaglandin I2 Synthase Monoclonal Antibody (Catalog # MAB7788) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Prostaglandin I2 Synthase at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Prostaglandin I2 Synthase Antibody - AF7788 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

Prostaglandin I2 Synthase Antibody - NBP1-62390 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTGIS Antibody [NBP1-62390] - Human Brain lysate, concentration 0.2-1 ug/ml.

Prostaglandin I2 Synthase Antibody - NBP1-85359 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTGIS Antibody [NBP1-85359] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Prostaglandin I2 Synthase Antibody - H00005740-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PTGIS Antibody [H00005740-A01] - PTGIS polyclonal antibody (A01), Lot # 050921JC01 Western Blot analysis of PTGIS expression in NIH/3T3 ( Cat # L018V1 ).

Prostaglandin I2 Synthase Antibody - H00005740-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Prostaglandin I2 Synthase Antibody - H00005740-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Prostaglandin I2 Synthase Antibody [H00005740-D01P] - Analysis of PTGIS expression in transfected 293T cell line by PTGIS polyclonal antibody.Lane 1: PTGIS transfected lysate(57.10 KDa).Lane 2: Non-transfected lysate.

Prostaglandin I2 Synthase Antibody (3B11) - H00005740-M02 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B11

Prostaglandin I2 Synthase Antibody - H00005740-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP8A1/PTGIS Polyclonal Antibody - bs-3677R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
B16 Cell lysates probed with CYP8A1/PTGIS Polyclonal Antibody, unconjugated (bs-3677R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

Anti-PTGIS antibody produced in rabbit - HPA014193 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PTGIS: <B>Cat. No. HPA014193</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-PTGIS antibody produced in mouse - SAB1406336 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PTGIS: <B>Cat. No. SAB1406336</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~55 kDa using PTGIS transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

ANTI-CYP8A1(N-TERMINAL) antibody produced in rabbit - SAB1306412 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP8A1 (N-term): <B>Cat. No. SAB1306412</B>: Western blot analysis of Anti-CYP8A1 Antibody (N-term) in Mouse lung tissue lysates (35 μg/lane).
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