| Gene Symbol |
LLGL2
|
| Entrez Gene |
3993
|
| Alt Symbol |
HGL, Hugl-2, LGL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lethal giant larvae homolog 2 (Drosophila)
|
| Other Description |
human giant larvae homolog|lethal(2) giant larvae protein homolog 2
|
| Swissprots |
Q6P1M3 Q14521 Q9BR62
|
| Accessions |
EAW89280 EAW89281 EAW89282 EAW89283 Q6P1M3 AK025401 AK125563 AK126687 BAG54359 AK301204 BAG62781 AK315126 BC006503 AAH06503 BC010879 AAH10879 BC031842 AAH31842 BC064994 AAH64994 BC067840 X87342 CAA60780 XM_006721897 XP_006721960 XM_011524801 XP_011523103 XM_011524802 XP_011523104 XM_011524803 XP_011523105 XM_011524804 XP_011523106 XM_011524805 XP_011523107 XM_011524806 XP_011523108 XM_011524807 XP_011523109 NM_001015002 NP_001015002 NM_001031803 NP_001026973 NM_004524 NP_004515
|
| Function |
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
|
| Top Pathways |
Tight junction, Hippo signaling pathway
|