LLGL2
| Gene Symbol | LLGL2 |
|---|---|
| Entrez Gene | 3993 |
| Alt Symbol | HGL, Hugl-2, LGL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lethal giant larvae homolog 2 (Drosophila) |
| Other Description | human giant larvae homolog|lethal(2) giant larvae protein homolog 2 |
| Swissprots | Q6P1M3 Q14521 Q9BR62 |
| Accessions | EAW89280 EAW89281 EAW89282 EAW89283 Q6P1M3 AK025401 AK125563 AK126687 BAG54359 AK301204 BAG62781 AK315126 BC006503 AAH06503 BC010879 AAH10879 BC031842 AAH31842 BC064994 AAH64994 BC067840 X87342 CAA60780 XM_006721897 XP_006721960 XM_011524801 XP_011523103 XM_011524802 XP_011523104 XM_011524803 XP_011523105 XM_011524804 XP_011523106 XM_011524805 XP_011523107 XM_011524806 XP_011523108 XM_011524807 XP_011523109 NM_001015002 NP_001015002 NM_001031803 NP_001026973 NM_004524 NP_004515 |
| Function | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. |
| Top Pathways | Tight junction, Hippo signaling pathway |
LLGL2 CRISPR/Cas9 KO Plasmid (h) - sc-404667 from Santa Cruz Biotechnology
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LLGL2 HDR Plasmid (h) - sc-404667-HDR from Santa Cruz Biotechnology
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LLGL2 Double Nickase Plasmid (h) - sc-404667-NIC from Santa Cruz Biotechnology
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LLGL2 Double Nickase Plasmid (h2) - sc-404667-NIC-2 from Santa Cruz Biotechnology
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LLGL2 CRISPR Activation Plasmid (h) - sc-404667-ACT from Santa Cruz Biotechnology
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LLGL2 CRISPR Activation Plasmid (h2) - sc-404667-ACT-2 from Santa Cruz Biotechnology
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LLGL2 Lentiviral Activation Particles (h) - sc-404667-LAC from Santa Cruz Biotechnology
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LLGL2 Lentiviral Activation Particles (h2) - sc-404667-LAC-2 from Santa Cruz Biotechnology
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LLGL2 siRNA (h) - sc-93661 from Santa Cruz Biotechnology
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LLGL2 shRNA Plasmid (h) - sc-93661-SH from Santa Cruz Biotechnology
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LLGL2 shRNA (h) Lentiviral Particles - sc-93661-V from Santa Cruz Biotechnology
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LLGL2 RNAi - H00003993-R02 from Novus Biologicals
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LLGL2 RNAi - H00003993-R04 from Novus Biologicals
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LLGL2 RNAi - H00003993-R06 from Novus Biologicals
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LLGL2 RNAi - H00003993-R05 from Novus Biologicals
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LLGL2 RNAi - H00003993-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11757 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11757 from Sigma-Aldrich
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LLGL2 siRNA (Human) - CRH2704 from Cohesion Biosciences
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LLGL2 RNAi - H00003993-R03 from Novus Biologicals
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shRNA set against Human LLGL2 (NM_004524.2) - SHH330835 from Creative biogene
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shRNA set against Human LLGL2(NM_001031803.1) - SHH151445 from Creative biogene
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shRNA set against Human LLGL2(NM_001015002.1) - SHH151463 from Creative biogene
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shRNA set against Human LLGL2(NM_004524.2) - SHH151481 from Creative biogene
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