LILRA3
| Gene Symbol | LILRA3 |
|---|---|
| Entrez Gene | 11026 |
| Alt Symbol | CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
| Other Description | CD85 antigen-like family member E|immunoglobulin-like transcript 6|leukocyte immunoglobulin-like receptor 4|leukocyte immunoglobulin-like receptor A3|leukocyte immunoglobulin-like receptor subfamily A member 3|monocyte inhibitory receptor HM43/HM31 |
| Swissprots | Q8N6C8 Q8N151 Q8NHJ3 Q8NHJ1 Q8NHJ2 Q8N154 J3KPM2 O15469 O75016 Q8NHJ4 O15470 |
| Accessions | AAK58867 AAM18035 AAM18036 AAM18037 AAM18038 AAM18039 AAM18040 AAM18041 AAM18042 CCF76528 CCF76529 EAW72225 Q8N6C8 AF014923 AAC51885 AF014924 AAC51886 AF025527 AAB87661 AI655471 BC028208 AAH28208 BX280714 DQ891075 ABM82001 DQ894258 ABM85184 U91926 AAB68666 U91927 AAB68667 XM_005277092 XP_005277149 XM_011547082 XP_011545384 XM_011547083 XP_011545385 XM_011547084 XP_011545386 XM_011547085 XP_011545387 XM_011547086 XP_011545388 XM_011547087 XP_011545389 XM_011547088 XP_011545390 XM_011547503 XP_011545805 XM_011547504 XP_011545806 XM_011547505 XP_011545807 XM_011547506 XP_011545808 XM_011547507 XP_011545809 XM_011548673 XP_011546975 XM_011548674 XP_011546976 XM_011548675 XP_011546977 XM_011548676 XP_011546978 XM_011548677 XP_011546979 NM_001172654 NP_001166125 NM_006865 NP_006856 |
| Function | Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS- induced TNF-alpha production by monocytes. {ECO:0000269|PubMed:21559424, ECO:0000269|PubMed:24085305}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung. {ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}. |
| Top Pathways | Osteoclast differentiation |
ILT-6 CRISPR/Cas9 KO Plasmid (h) - sc-411552 from Santa Cruz Biotechnology
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ILT-6 HDR Plasmid (h) - sc-411552-HDR from Santa Cruz Biotechnology
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ILT-6 Double Nickase Plasmid (h) - sc-411552-NIC from Santa Cruz Biotechnology
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ILT-6 Double Nickase Plasmid (h2) - sc-411552-NIC-2 from Santa Cruz Biotechnology
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ILT-6 CRISPR Activation Plasmid (h) - sc-411552-ACT from Santa Cruz Biotechnology
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ILT-6 CRISPR Activation Plasmid (h2) - sc-411552-ACT-2 from Santa Cruz Biotechnology
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ILT-6 Lentiviral Activation Particles (h) - sc-411552-LAC from Santa Cruz Biotechnology
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ILT-6 Lentiviral Activation Particles (h2) - sc-411552-LAC-2 from Santa Cruz Biotechnology
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ILT-6 siRNA (h) - sc-105617 from Santa Cruz Biotechnology
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ILT-6 shRNA Plasmid (h) - sc-105617-SH from Santa Cruz Biotechnology
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ILT-6 shRNA (h) Lentiviral Particles - sc-105617-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109111 from Sigma-Aldrich
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MISSION® esiRNA - EHU113351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11708 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11708 from Sigma-Aldrich
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LILRA3 siRNA (Human) - CRH7535 from Cohesion Biosciences
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ILT6/CD85e/LILRA3 RNAi - H00011026-R02 from Novus Biologicals
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shRNA set against Human LILRA3 (NM_006865.3) - SHH330271 from Creative biogene
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Human LILRA3 siRNA - orb268037 from Biorbyt
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LILRA3 shRNA Plasmid (Human) - CHH7535 from Cohesion Biosciences
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LILRA3 miRNA 3'UTR clone - MiUTR3H-07117 from Creative biogene
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