| Gene Symbol |
SLX4
|
| Entrez Gene |
84464
|
| Alt Symbol |
BTBD12, FANCP, MUS312
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLX4 structure-specific endonuclease subunit
|
| Other Description |
BTB (POZ) domain containing 12|BTB/POZ domain-containing protein 12|SLX4 structure-specific endonuclease subunit homolog|structure-specific endonuclease subunit SLX4
|
| Swissprots |
Q8TF15 Q69YT8 Q96JP1 Q8IY92
|
| Accessions |
EAW85345 EAW85346 EAW85347 Q8IY92 AB058687 BAB47413 AB075867 BAB85573 AK095411 AK122775 AL442083 CAH10659 BC029952 BC036335 BC104222 BC104223 BC112989 BC112990 BE887716 BM541728 XM_011522715 XP_011521017 NM_032444 NP_115820
|
| Function |
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure- specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81- EME1 endonuclease and promotes the cleavage of 3'-fl
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. Note=Localizes to sites of DNA dammage.
|
| Top Pathways |
Fanconi anemia pathway
|