SLX4

Gene Symbol SLX4
Entrez Gene 84464
Alt Symbol BTBD12, FANCP, MUS312
Species Human
Gene Type protein-coding
Description SLX4 structure-specific endonuclease subunit
Other Description BTB (POZ) domain containing 12|BTB/POZ domain-containing protein 12|SLX4 structure-specific endonuclease subunit homolog|structure-specific endonuclease subunit SLX4
Swissprots Q8TF15 Q69YT8 Q96JP1 Q8IY92
Accessions EAW85345 EAW85346 EAW85347 Q8IY92 AB058687 BAB47413 AB075867 BAB85573 AK095411 AK122775 AL442083 CAH10659 BC029952 BC036335 BC104222 BC104223 BC112989 BC112990 BE887716 BM541728 XM_011522715 XP_011521017 NM_032444 NP_115820
Function Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure- specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81- EME1 endonuclease and promotes the cleavage of 3'-fl
Subcellular Location Nucleus {ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. Note=Localizes to sites of DNA dammage.
Top Pathways Fanconi anemia pathway

BTBD12 CRISPR/Cas9 KO Plasmid (h) - sc-404395 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 HDR Plasmid (h) - sc-404395-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 Double Nickase Plasmid (h) - sc-404395-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 Double Nickase Plasmid (h2) - sc-404395-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 CRISPR Activation Plasmid (h) - sc-404395-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 CRISPR Activation Plasmid (h2) - sc-404395-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 Lentiviral Activation Particles (h) - sc-404395-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 Lentiviral Activation Particles (h2) - sc-404395-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BTBD12 siRNA (h) - sc-93088 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BTBD12 shRNA Plasmid (h) - sc-93088-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BTBD12 shRNA (h) Lentiviral Particles - sc-93088-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19747 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19747 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08819 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08819

SLX4 siRNA (Human) - CRJ3490 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLX4 - MBS8212037 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Slx (NM_032444.2) - SHH412896 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human BTBD12(NM_032444.2) - SHG106579 from Creative biogene

Category siRNA
Species Reactivities Human

SLX4 shRNA Plasmid (Human) - CHJ3490 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLX4 miRNA 3'UTR clone - MiUTR1H-00967 from Creative biogene

Species Reactivities Human
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