SLX4

Gene Symbol SLX4
Entrez Gene 84464
Alt Symbol BTBD12, FANCP, MUS312
Species Human
Gene Type protein-coding
Description SLX4 structure-specific endonuclease subunit
Other Description BTB (POZ) domain containing 12|BTB/POZ domain-containing protein 12|SLX4 structure-specific endonuclease subunit homolog|structure-specific endonuclease subunit SLX4
Swissprots Q8TF15 Q69YT8 Q96JP1 Q8IY92
Accessions EAW85345 EAW85346 EAW85347 Q8IY92 AB058687 BAB47413 AB075867 BAB85573 AK095411 AK122775 AL442083 CAH10659 BC029952 BC036335 BC104222 BC104223 BC112989 BC112990 BE887716 BM541728 XM_011522715 XP_011521017 NM_032444 NP_115820
Function Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure- specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81- EME1 endonuclease and promotes the cleavage of 3'-fl
Subcellular Location Nucleus {ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. Note=Localizes to sites of DNA dammage.
Top Pathways Fanconi anemia pathway

SLX4 peptide - ab116498 from Abcam

Category Peptide

SLX4 Antibody Blocking Peptide - LS-E21913 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

BTBD12 Blocking Peptide - 33R-9152 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Recombinant Human Structure-specific endonuclease subunit SLX4(SLX4) ,partial - CSB-YP810299HU CSB-EP810299HU CSB-BP810299HU CSB-MP810299HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

BTBD12 Recombinant Protein Antigen - NBP2-39070PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SLX4 Peptide, Human - M34GP14710H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Structure-specific endonuclease subunit SLX4 (603-615) - ta-169 from Creative Peptides

Category Peptide
Source Homo sapiens (human)

Structure-specific endonuclease subunit SLX4 (SLX4), Recombinant Protein - MBS1347970 from MyBioSource

Category Protein
Prices $1,285.00, $1,285.00, $1,505.00, $1,505.00, $2,110.00, $2,110.00, $2,570.00, $2,570.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Ashbya gossypii

Structure-specific endonuclease subunit SLX4 (SLX4), partial, Recombinant Protein - MBS1464305 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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