VDAC1

Gene Symbol	VDAC1
Entrez Gene	7416
Alt Symbol	PORIN, VDAC-1
Species	Human
Gene Type	protein-coding
Description	voltage-dependent anion channel 1
Other Description	outer mitochondrial membrane protein porin 1|plasmalemmal porin|porin 31HL|porin 31HM|voltage-dependent anion-selective channel protein 1
Swissprots	Q9UPL0 D3DQ93 P21796 Q5FVE7 B3KVK4 Q9UIQ5
Accessions	AAC24723 AAD54939 CAB58127 EAW62281 EAW62282 EAW62283 EAW62284 EAW62285 EAW62286 P21796 AK095989 BAG53187 AK122953 BAG53816 AK293639 BAG57094 BC008482 AAH08482 BC071168 AAH71168 BC090042 AAH90042 DA072915 DB475162 DQ893183 ABM84109 DQ896492 ABM87491 L06132 AAA61272 XM_005272075 XP_005272132 NM_003374 NP_003365 NR_036624 NR_036625
Function	Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:7539795}. Cell membrane {ECO:0000269|PubMed:7539795}.
Tissue Specificity	Heart, liver and skeletal muscle.
Top Pathways	Huntington's disease, Calcium signaling pathway, HTLV-I infection, Influenza A, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VDAC1 / Porin peptide - ab16131 from Abcam Category Peptide Species Human

Human VDAC1 / Porin peptide - ab95341 from Abcam Category Peptide Species Human

Human VDAC1/Porin full length protein - ab132481 from Abcam Category Protein Source Wheat germ Species Human

Human VDAC1/Porin protein fragment - ab159798 from Abcam Category Protein Source Wheat germ Species Human

Human VDAC1/Porin protein fragment - ab159799 from Abcam Category Protein Source Wheat germ Species Human

Human VDAC1/Porin protein fragment - ab159800 from Abcam Category Protein Source Wheat germ Species Human

VDAC1/Porin peptide - ab109894 from Abcam Category Peptide

VDAC1 / PORIN Antibody Blocking Peptide - LS-E8340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VDAC1 / PORIN Antibody Blocking Peptide - LS-E8339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human VDAC1 Protein - H00007416-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human VDAC1 Protein - H00007416-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human VDAC1 Protein - H00007416-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human VDAC1 Protein - H00007416-Q03 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VDAC1-Antibody-Center-Blocking-Peptide - BP6627c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VDAC1-Antibody-N-term-Blocking-Peptide - BP6627a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VDAC/Porin Blocking Peptide - 33R-10515 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

VDAC1 Blocking Peptide - 33R-8303 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VDAC1 - H00007416-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VDAC1 - H00007416-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VDAC1 - H00007416-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VDAC1 - H00007416-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VDAC1 - H00007416-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

VDAC1 - H00007416-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VDAC1 - H00007416-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VDAC1 - H00007416-Q03 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

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