VDAC1

Gene Symbol VDAC1
Entrez Gene 7416
Alt Symbol PORIN, VDAC-1
Species Human
Gene Type protein-coding
Description voltage-dependent anion channel 1
Other Description outer mitochondrial membrane protein porin 1|plasmalemmal porin|porin 31HL|porin 31HM|voltage-dependent anion-selective channel protein 1
Swissprots Q9UPL0 D3DQ93 P21796 Q5FVE7 B3KVK4 Q9UIQ5
Accessions AAC24723 AAD54939 CAB58127 EAW62281 EAW62282 EAW62283 EAW62284 EAW62285 EAW62286 P21796 AK095989 BAG53187 AK122953 BAG53816 AK293639 BAG57094 BC008482 AAH08482 BC071168 AAH71168 BC090042 AAH90042 DA072915 DB475162 DQ893183 ABM84109 DQ896492 ABM87491 L06132 AAA61272 XM_005272075 XP_005272132 NM_003374 NP_003365 NR_036624 NR_036625
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:7539795}. Cell membrane {ECO:0000269|PubMed:7539795}.
Tissue Specificity Heart, liver and skeletal muscle.
Top Pathways Huntington's disease, Calcium signaling pathway, HTLV-I infection, Influenza A, cGMP-PKG signaling pathway

VDAC (D73D12) Rabbit mAb (HRP Conjugate) - 12454 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D73D12
Western blot analysis of extracts from COS-7 and HeLa cells using VDAC (D73D12) Rabbit mAb (HRP Conjugate).

VDAC Antibody - 4866 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using VDAC Antibody.

VDAC (D73D12) Rabbit mAb - 4661 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D73D12
Western blot analysis of extracts from various cell types using VDAC (D73D12) Rabbit mAb.

VDAC1 (B-6) - sc-390996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VDAC1 (B-6): sc-390996. Western blot analysis of VDAC1 expression in HL-60 (A), Jurkat (D), HeLa (E) and A-431 (F) whole cell lysates and rat heart (B) and human heart (C) tissue extracts.

VDAC1 (C-20) - sc-8829 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

VDAC1 (D-16) - sc-32063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VDAC1 (D-16): sc-32063. Western blot analysis of VDAC1 expression in HL-60 whole cell lysate.

VDAC1 (K-20) - sc-32064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VDAC1 (K-20): sc-32064. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of glandular cells.

VDAC1 (N-18) - sc-8828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VDAC1 (N-18): sc-8828. Western blot analysis of VDAC1 expression in rat heart tissue extract.

VDAC1/2/3 (FL-283) - sc-98708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VDAC1/2/3 (FL-283): sc-98708. Western blot analysis of VDAC1/2/3 expression in HL-60 (A) and Jurkat (B) whole cell lysates.

Anti-VDAC1 / Porin antibody - ab119296 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab119296 at 2.5 &microg/ml staining VDAC1 / Porin in Human Liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-VDAC1 / Porin antibody - ab85123 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-VDAC1 / Porin antibody (ab85123) at 1/250 dilution + HepG2 cell lysate

Anti-VDAC1 / Porin antibody [20B12] - Azide free - ab175615 from Abcam

Prices $2,342.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal
Clone 20B12

Anti-VDAC1 / Porin antibody [20B12AF2] - ab14734 from Abcam

Prices $401.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 20B12AF2
Anti-VDAC1 / Porin antibody [20B12AF2] (ab14734) at 1 µg/ml + Bovine Heart Mitochondria at 10 µgSecondaryGoat anti-mouse-HRP (1:5000)developed using the ECL techniquePerformed under reducing conditions.

Anti-VDAC1 / Porin antibody [20B12AF2] (Alexa Fluor® 488) - ab179839 from Abcam

Prices $431.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 20B12AF2
Flow Cytometry for ab179839 stained HeLa cells.Flow cytometry results of unstained cells (black), stained cells (0.2 µg/mL, red).   

Anti-VDAC1 / Porin antibody [EPR10852(B)] - Mitochondrial Loading Control - ab154856 from Abcam

Prices $388.00, $776.00
Sizes 100 µl, 250 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10852(B)
Anti-VDAC1 / Porin antibody [EPR10852(B)] - Mitochondrial Loading Control (ab154856) at 1/5000 dilution + Rat cerebellum whole tissue lysate at 30 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97069) (undiluted)developed using the ECL techniquePerformed under reducing conditions.

Anti-VDAC1/Porin antibody - ab150616 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human heart tissue labelling VDAC1/Porin with ab150616 antibody at a dilution of 1/200.

Anti-VDAC1/Porin antibody - ab76441 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-VDAC1/Porin antibody (ab76441) at 1/500 dilution + immunogen at 0.1 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-VDAC1/Porin antibody [S152B-23] - ab186321 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S152B-23

Anti-VDAC1/Porin antibody - N-terminal - ab135585 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab135585 stained HeLa cells. The cells were 4% formaldehyde fixed for 10 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab135585 at 5µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-VDAC1/Porin antibody - N-terminal - ab190619 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-VDAC1/Porin antibody - N-terminal (ab190619) at 1/500 dilution + K562 cell extract at 30 µg

Anti-VDAC1 / PORIN Antibody (clone 2E10) - LS-C139068 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E10

Anti-VDAC1 / PORIN Antibody (aa189) - LS-C190264 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VDAC1 / PORIN Antibody (C-Terminus) - LS-C30692 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
VDAC1 antibody LS-C30692 was used in IHC to stain formalin-fixed, paraffin-embedded human liver.

Anti-VDAC1 / PORIN Antibody (aa1-283, clone S152B-23) - LS-C209548 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S152B-23

Anti-VDAC1 / PORIN Antibody (aa1-283, clone S152B-23, Atto 390) - LS-C229242 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S152B-23
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