VDAC1

Gene Symbol VDAC1
Entrez Gene 7416
Alt Symbol PORIN, VDAC-1
Species Human
Gene Type protein-coding
Description voltage-dependent anion channel 1
Other Description outer mitochondrial membrane protein porin 1|plasmalemmal porin|porin 31HL|porin 31HM|voltage-dependent anion-selective channel protein 1
Swissprots Q9UPL0 D3DQ93 P21796 Q5FVE7 B3KVK4 Q9UIQ5
Accessions AAC24723 AAD54939 CAB58127 EAW62281 EAW62282 EAW62283 EAW62284 EAW62285 EAW62286 P21796 AK095989 BAG53187 AK122953 BAG53816 AK293639 BAG57094 BC008482 AAH08482 BC071168 AAH71168 BC090042 AAH90042 DA072915 DB475162 DQ893183 ABM84109 DQ896492 ABM87491 L06132 AAA61272 XM_005272075 XP_005272132 NM_003374 NP_003365 NR_036624 NR_036625
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:7539795}. Cell membrane {ECO:0000269|PubMed:7539795}.
Tissue Specificity Heart, liver and skeletal muscle.
Top Pathways Huntington's disease, Calcium signaling pathway, HTLV-I infection, Influenza A, cGMP-PKG signaling pathway

VDAC1 CRISPR/Cas9 KO Plasmid (h) - sc-418200 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 HDR Plasmid (h) - sc-418200-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 Double Nickase Plasmid (h) - sc-418200-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 Double Nickase Plasmid (h2) - sc-418200-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 CRISPR Activation Plasmid (h) - sc-418200-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 CRISPR Activation Plasmid (h2) - sc-418200-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 Lentiviral Activation Particles (h) - sc-418200-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 Lentiviral Activation Particles (h2) - sc-418200-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDAC1 siRNA (h) - sc-42355 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VDAC1 shRNA Plasmid (h) - sc-42355-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VDAC1 shRNA (h) Lentiviral Particles - sc-42355-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VDAC1 RNAi - H00007416-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU109131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22664 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22664 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06620 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06620

VDAC1 siRNA (Human) - CRH5074 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VDAC1 - MBS8219586 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human VDAC1 siRNA - orb265576 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VDAC1 shRNA Plasmid (Human) - CHH5074 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VDAC1 miRNA 3'UTR clone - MiUTR3H-06850 from Creative biogene

Species Reactivities Human
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