| Gene Symbol |
IFIT5
|
| Entrez Gene |
24138
|
| Alt Symbol |
ISG58, P58, RI58
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon-induced protein with tetratricopeptide repeats 5
|
| Other Description |
IFIT-5|interferon-induced 58 kDa protein|retinoic acid- and interferon-inducible 58 kDa protein|retinoic acid- and interferon-inducible protein (58kD)
|
| Swissprots |
Q6IAX3 Q5T7I9 B4DDV1 B2R5X9 Q13325
|
| Accessions |
EAW50135 Q13325 AK293346 BAG56862 AK312358 BAG35276 BC025786 AAH25786 CR457031 CAG33312 DC392439 U34605 AAA84934 NM_012420 NP_036552
|
| Function |
Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP- RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs. {ECO:0000269|PubMed:23317505, ECO:0000269|PubMed:23334420}.
|
| Subcellular Location |
Cell projection, ruffle membrane {ECO:0000269|PubMed:23317505}. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
|