| Gene Symbol |
GPR35
|
| Entrez Gene |
2859
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 35
|
| Other Description |
G-protein coupled receptor 35|KYNA receptor|kynurenic acid receptor
|
| Swissprots |
Q4VBN5 Q86UH4 Q9HC97 O43495 J3KR30 Q6FHI8 Q17R58 Q4ZFV2
|
| Accessions |
AAC52028 AAP32299 AAX88945 EAW71209 EAW71210 Q9HC97 AF089087 AAG17965 AK131540 BAD18676 AK172786 AK290256 BAF82945 AK314002 BAG36714 AW000832 BC095500 AAH95500 BC117453 AAI17454 BC117455 AAI17456 BM857130 CR541765 CAG46564 DB011311 NM_001195381 NP_001182310 NM_001195382 NP_001182311 NM_005301 NP_005292
|
| Function |
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269|PubMed:16754668}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16754668}; Multi-pass membrane protein {ECO:0000269|PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
|
| Tissue Specificity |
Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269|PubMed:16754668}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|
![Western Blot: GPR35 Overexpression Lysate (Adult Normal) [NBP2-04288] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GPR35.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9876_GPR35%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04288-img0001.jpg)