Gene Symbol | GPR35 |
---|---|
Entrez Gene | 2859 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor 35 |
Other Description | G-protein coupled receptor 35|KYNA receptor|kynurenic acid receptor |
Swissprots | Q4VBN5 Q86UH4 Q9HC97 O43495 J3KR30 Q6FHI8 Q17R58 Q4ZFV2 |
Accessions | AAC52028 AAP32299 AAX88945 EAW71209 EAW71210 Q9HC97 AF089087 AAG17965 AK131540 BAD18676 AK172786 AK290256 BAF82945 AK314002 BAG36714 AW000832 BC095500 AAH95500 BC117453 AAI17454 BC117455 AAI17456 BM857130 CR541765 CAG46564 DB011311 NM_001195381 NP_001182310 NM_001195382 NP_001182311 NM_005301 NP_005292 |
Function | Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269|PubMed:16754668}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16754668}; Multi-pass membrane protein {ECO:0000269|PubMed:16754668}. Note=Internalized to the cytoplasm after exposure to kynurenic acid. |
Tissue Specificity | Predominantly expressed in immune and gastrointestinal tissues. {ECO:0000269|PubMed:16754668}. |
Top Pathways | Neuroactive ligand-receptor interaction |