FERMT2

Gene Symbol	FERMT2
Entrez Gene	10979
Alt Symbol	KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Species	Human
Gene Type	protein-coding
Description	fermitin family member 2
Other Description	PH domain-containing family C member 1\|fermitin family homolog 2\|kindlin 2\|kindlin-2\|mitogen inducible gene 2 protein\|mitogen-inducible gene 2 protein\|pleckstrin homology domain containing, family C (with FERM domain) member 1\|pleckstrin homology domain containing, family C member 1\|pleckstrin homology domain-containing family C member 1
Swissprots	B5TJY2 Q96AC1 Q86TY7 Q14840
Accessions	EAW80618 EAW80619 EAW80620 Q96AC1 AF443279 AAN75823 AK126426 AK291738 BAF84427 BC011125 BC017327 AAH17327 BX161467 CAD61925 CR749486 EU831994 ACE87435 EU832087 ACE86749 EU979385 ACH73257 Z24725 CAA80852 XM_005267285 XP_005267342 XM_006720008 XP_006720071 XM_006720009 XP_006720072 XM_006720010 XP_006720073 NM_001134999 NP_001128471 NM_001135000 NP_001128472 NM_006832 NP_006823
Function	Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269\|PubMed:12679033, ECO:0000269\|PubMed:18458155, ECO:0000269\|PubMed:21325030, ECO:0000269\|PubMed:22030399, ECO:0000269\|PubMed:22078565, ECO:0000269\|PubMed:22699938}.
Subcellular Location	Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Tissue Specificity	Ubiquitous. Found in numerous tumor tissues.

Kindlin-2 Antibody - 13562 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa, Saos-2, and MCF7 cells using Kindlin-2 Antibody.

Mig-2 (Y-15) - sc-30854 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Mig-2 (Y-15): sc-30854. Immunofluorescence staining of normal mouse intestine frozen section showing cytoskeletal staining.

Mig-2 (H-57) - sc-292419 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Mig-2 (H-57): sc-292419. Western blot analysis of Mig-2 expression in MDCK (A) and PC-12 (B) whole cell lysates.

Mig-2 (NQ-A16) - sc-134387 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Mig-2 (NQ-A16): sc-134387. Western blot analysis of Mig-2 expression in human Mig-2 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-Kindlin 2 antibody [22E7] - ab117962 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	22E7

All lanes : Anti-Kindlin 2 antibody [22E7] (ab117962) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY Kindlin 2 cDNALysates/proteins at 5 µg per lane.

Anti-Kindlin 2 antibody - C-terminal - ab139106 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Kindlin 2 antibody - C-terminal (ab139106) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

Anti-KIND2 / FERMT2 Antibody (clone 14A11) - LS-C114604 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	14A11

IHC of paraffin-embedded pancreas tissue using anti-FERMT2 mouse monoclonal antibody. (Dilution 1:50).

Anti-KIND2 / FERMT2 Antibody (clone 25A4) - LS-C114606 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	25A4

Anti-KIND2 / FERMT2 Antibody - LS-C130353 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-KIND2 / FERMT2 Antibody (aa321-444, clone 1D4B) - LS-C189810 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1D4B

Anti-KIND2 / FERMT2 Antibody (aa641-669, Biotin) - LS-C257194 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669, APC) - LS-C257195 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669, FITC) - LS-C257196 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669, Azide-free, HRP) - LS-C257197 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669, PE) - LS-C257198 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669, AP) - LS-C259375 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669) - LS-C321353 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa402-451) - LS-C170471 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KIND2 / FERMT2 Antibody (aa641-669) - LS-C159641 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

FERMT2 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The FERMT2 antibody detected the FERMT2 protein (arrow).

Anti-KIND2 / FERMT2 Antibody (clone 22E7) - LS-C114608 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	22E7

Immunofluorescent staining of HeLa cells using anti-FERMT2 mouse monoclonal antibody.

Anti-KIND2 / FERMT2 Antibody (clone 9E4) - LS-C114603 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	9E4

IHC of paraffin-embedded Ovary tissue using anti-FERMT2 mouse monoclonal antibody. (Dilution 1:50).

MIG2/Kindlin-2 Antibody (9E4) - NBP1-47745 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	9E4

Western Blot: MIG2/Kindlin-2 Antibody (9E4) [NBP1-47745] - Analysis of extracts (35ug) from 9 different cell lines by using anti-Kindlin-2 monoclonal antibody.

MIG2/Kindlin-2 Antibody (696906) - MAB6984 from Novus Biologicals

Prices	$99.00, $249.00
Sizes	25 µg, 100 µg
Host	Mouse
Clonality	Monoclonal
Clone	696906

MIG2/Kindlin-2 Antibody - NBP1-87884 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Kindlin-2 Antibody [NBP1-87884] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

MIG2/Kindlin-2 Antibody - NBP2-17059 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Kindlin-2 Antibody [NBP2-17059] - Sample (30 ug of whole cell lysate) A: PC-12 7. 5% SDS PAGE gel, diluted at 1:3000.

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