| Gene Symbol |
FERMT2
|
| Entrez Gene |
10979
|
| Alt Symbol |
KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fermitin family member 2
|
| Other Description |
PH domain-containing family C member 1|fermitin family homolog 2|kindlin 2|kindlin-2|mitogen inducible gene 2 protein|mitogen-inducible gene 2 protein|pleckstrin homology domain containing, family C (with FERM domain) member 1|pleckstrin homology domain containing, family C member 1|pleckstrin homology domain-containing family C member 1
|
| Swissprots |
B5TJY2 Q96AC1 Q86TY7 Q14840
|
| Accessions |
EAW80618 EAW80619 EAW80620 Q96AC1 AF443279 AAN75823 AK126426 AK291738 BAF84427 BC011125 BC017327 AAH17327 BX161467 CAD61925 CR749486 EU831994 ACE87435 EU832087 ACE86749 EU979385 ACH73257 Z24725 CAA80852 XM_005267285 XP_005267342 XM_006720008 XP_006720071 XM_006720009 XP_006720072 XM_006720010 XP_006720073 NM_001134999 NP_001128471 NM_001135000 NP_001128472 NM_006832 NP_006823
|
| Function |
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
|
| Tissue Specificity |
Ubiquitous. Found in numerous tumor tissues.
|