FERMT2

Gene Symbol FERMT2
Entrez Gene 10979
Alt Symbol KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Species Human
Gene Type protein-coding
Description fermitin family member 2
Other Description PH domain-containing family C member 1|fermitin family homolog 2|kindlin 2|kindlin-2|mitogen inducible gene 2 protein|mitogen-inducible gene 2 protein|pleckstrin homology domain containing, family C (with FERM domain) member 1|pleckstrin homology domain containing, family C member 1|pleckstrin homology domain-containing family C member 1
Swissprots B5TJY2 Q96AC1 Q86TY7 Q14840
Accessions EAW80618 EAW80619 EAW80620 Q96AC1 AF443279 AAN75823 AK126426 AK291738 BAF84427 BC011125 BC017327 AAH17327 BX161467 CAD61925 CR749486 EU831994 ACE87435 EU832087 ACE86749 EU979385 ACH73257 Z24725 CAA80852 XM_005267285 XP_005267342 XM_006720008 XP_006720071 XM_006720009 XP_006720072 XM_006720010 XP_006720073 NM_001134999 NP_001128471 NM_001135000 NP_001128472 NM_006832 NP_006823
Function Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
Subcellular Location Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Tissue Specificity Ubiquitous. Found in numerous tumor tissues.

Human Kindlin 2 full length protein - ab132759 from Abcam

Category Protein
Source Wheat germ
Species Human
ab132759 on 12.5% SDS-PAGE stained with Coomassie blue.

Human Kindlin 2 peptide - ab74029 from Abcam

Category Peptide

KIND2 / FERMT2 Antibody Blocking Peptide - LS-E6290 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

KIND2 / FERMT2 Antibody Blocking Peptide - LS-E24557 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human MIG2/Kindlin-2 Protein - H00010979-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

FERMT2-Antibody-C-term-Blocking-Peptide - BP18977b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

FERMT2 / PLEKHC1 - H00010979-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

FERMT2 / PLEKHC1 - H00010979-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Kindlin 2 fusion protein - Ag2013 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human FERMT2, GST-tagged - FERMT2-12845H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Fermitin family homolog 2(FERMT2) - CSB-YP853382HU CSB-EP853382HU CSB-BP853382HU CSB-MP853382HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

FERMT2 / PLEKHC1 (transcript variant 1) - TP305727 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
FERMT2 / PLEKHC1

MIG2/Kindlin-2 Protein - NBP1-87884PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

FERMT2 Peptide, Human - M34GP05675H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Fermitin family homolog 2 (FERMT2), Recombinant Protein - MBS1350321 from MyBioSource

Category Protein
Prices $1,485.00, $1,485.00, $1,710.00, $1,710.00, $2,530.00, $2,530.00, $2,970.00, $2,970.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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