FERMT2

Gene Symbol	FERMT2
Entrez Gene	10979
Alt Symbol	KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Species	Human
Gene Type	protein-coding
Description	fermitin family member 2
Other Description	PH domain-containing family C member 1|fermitin family homolog 2|kindlin 2|kindlin-2|mitogen inducible gene 2 protein|mitogen-inducible gene 2 protein|pleckstrin homology domain containing, family C (with FERM domain) member 1|pleckstrin homology domain containing, family C member 1|pleckstrin homology domain-containing family C member 1
Swissprots	B5TJY2 Q96AC1 Q86TY7 Q14840
Accessions	EAW80618 EAW80619 EAW80620 Q96AC1 AF443279 AAN75823 AK126426 AK291738 BAF84427 BC011125 BC017327 AAH17327 BX161467 CAD61925 CR749486 EU831994 ACE87435 EU832087 ACE86749 EU979385 ACH73257 Z24725 CAA80852 XM_005267285 XP_005267342 XM_006720008 XP_006720071 XM_006720009 XP_006720072 XM_006720010 XP_006720073 NM_001134999 NP_001128471 NM_001135000 NP_001128472 NM_006832 NP_006823
Function	Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
Subcellular Location	Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Tissue Specificity	Ubiquitous. Found in numerous tumor tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Fermitin family homolog 2, FERMT2, Human, ELISA Kit - E2726h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

fermitin family homolog 2 (Drosophila) , ELISA Kit - MBS9340873 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The sensitivity of this kit is 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Kindlin 2 (KIND2), ELISA Kit - MBS9302285 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse KIND2 / FERMT2 ELISA Kit (Custom ELISA) - LS-F19783 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Human KIND2 / FERMT2 ELISA Kit (Custom ELISA) - LS-F19784 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Human FERMT2 ELISA Kit - E014684 from Biobool Category ELISA Kit Sensitivity The sensitivity of this kit is 1.0 ng/ml.

Human KIND2 ELISA Kit - E021813 from Biobool Category ELISA Kit

FERMT2 ELISA Kit (Human) (OKEH05154) - OKEH05154 from Aviva Systems Biology Category ELISA Kit Prices $440.00 Sizes 96 wells Sensitivity 39 pg/mL Range 78-5,000 pg/mL

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9359457 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9358949 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9362126 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9362349 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9356532 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9363847 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9345602 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9348805 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9367866 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9370175 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9360073 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9363010 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9359832 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9350836 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin family homolog 2, ELISA Kit - MBS2882152 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9356746 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Fermitin Family Homolog 2 (FERMT2), ELISA Kit - MBS9365367 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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