Gene Symbol | TPCN2 |
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Entrez Gene | 219931 |
Alt Symbol | SHEP10, TPC2 |
Species | Human |
Gene Type | protein-coding |
Description | two pore segment channel 2 |
Other Description | two pore calcium channel protein 2|two-pore calcium channel protein 2|voltage-dependent calcium channel protein TPC2 |
Swissprots | Q9NT82 Q8NHX9 |
Accessions | EAW74734 EAW74735 EAW74736 EAW74737 Q8NHX9 AB209253 BAD92490 AK023366 BAG51185 AK123089 AK298919 BAG61025 AL137479 CAB70760 AW177543 AY029200 AAK31802 BC063008 AAH63008 BP380645 CD636711 HG503921 HG503922 XM_005273824 XP_005273881 XM_005273826 XP_005273883 XM_005273827 XP_005273884 XM_005273828 XP_005273885 XM_005273830 XP_005273887 XM_005273831 XP_005273888 XM_005273832 XP_005273889 XM_006718453 XP_006718516 XM_006718454 XP_006718517 XM_006718456 XP_006718519 XM_011544802 XP_011543104 XM_011544803 XP_011543105 XM_011544804 XP_011543106 XM_011544805 XP_011543107 XM_011544806 XP_011543108 XM_011544807 XP_011543109 XM_011544808 XP_011543110 XR_247191 NM_139075 NP_620714 |
Function | Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}. |
Subcellular Location | Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}. |
Tissue Specificity | Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}. |
Top Pathways | Pancreatic secretion |
TPCN2 (D-14) - sc-162344 from Santa Cruz Biotechnology
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TPCN2 (G-15) - sc-162345 from Santa Cruz Biotechnology
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TPCN2 (H-53) - sc-383009 from Santa Cruz Biotechnology
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Anti-Two pore calcium channel protein 2 antibody - ab119915 from Abcam
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Anti-Two pore calcium channel protein 2 antibody - ab111145 from Abcam
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Anti-TPC2 / TPCN2 Antibody (aa700-752) - LS-C95186 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (aa240-252) - LS-C3241 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (aa727-740) - LS-C3240 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (Cytoplasmic Domain) - LS-C95187 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (Cytoplasmic Domain) - LS-C95188 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (N-Terminus) - LS-C178859 from LifeSpan Bioscience
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Anti-TPC2 / TPCN2 Antibody (aa735-747) IHC-plus⢠- LS-B4183 from LifeSpan Bioscience
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Two pore calcium channel protein 2 Antibody - NBP1-30676 from Novus Biologicals
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Two pore calcium channel protein 2 Antibody - NBP1-86923 from Novus Biologicals
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Two pore calcium channel protein 2 Antibody - NBP1-45234 from Novus Biologicals
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Anti-TPCN2 antibody produced in rabbit - HPA027080 from Sigma-Aldrich
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TPCN2-Antibody-C-Term - AF3011a from Abgent, a WuXi AppTec company
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TPCN2 antibody - orb77572 from Biorbyt
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TPCN2 Antibody (OAEB00169) - OAEB00169 from Aviva Systems Biology
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TPCN2 Antibody - abx037591 from Abbexa
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TPCN2 (735-747) antibody - AP23140PU-N from Acris Antibodies
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Anti-Two Pore Calcium Channel Protein 2 Antibody - AC21-1983 from Abcore
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Anti-Two Pore Calcium Channel Protein 2 Antibody (AMCA) - AC21-1983-01 from Abcore
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Anti-Two Pore Calcium Channel Protein 2 Antibody (AP) - AC21-1983-02 from Abcore
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Anti-Two Pore Calcium Channel Protein 2 Antibody (APC) - AC21-1983-03 from Abcore
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