| Gene Symbol | TPCN2 |
|---|---|
| Entrez Gene | 219931 |
| Alt Symbol | SHEP10, TPC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | two pore segment channel 2 |
| Other Description | two pore calcium channel protein 2|two-pore calcium channel protein 2|voltage-dependent calcium channel protein TPC2 |
| Swissprots | Q9NT82 Q8NHX9 |
| Accessions | EAW74734 EAW74735 EAW74736 EAW74737 Q8NHX9 AB209253 BAD92490 AK023366 BAG51185 AK123089 AK298919 BAG61025 AL137479 CAB70760 AW177543 AY029200 AAK31802 BC063008 AAH63008 BP380645 CD636711 HG503921 HG503922 XM_005273824 XP_005273881 XM_005273826 XP_005273883 XM_005273827 XP_005273884 XM_005273828 XP_005273885 XM_005273830 XP_005273887 XM_005273831 XP_005273888 XM_005273832 XP_005273889 XM_006718453 XP_006718516 XM_006718454 XP_006718517 XM_006718456 XP_006718519 XM_011544802 XP_011543104 XM_011544803 XP_011543105 XM_011544804 XP_011543106 XM_011544805 XP_011543107 XM_011544806 XP_011543108 XM_011544807 XP_011543109 XM_011544808 XP_011543110 XR_247191 NM_139075 NP_620714 |
| Function | Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}. |
| Subcellular Location | Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}. |
| Top Pathways | Pancreatic secretion |
two pore segment channel 2, ELISA Kit - MBS9329798 from MyBioSource
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Human TPCN2 ELISA Kit - E040089 from Biobool
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Two pore calcium channel protein 2, ELISA Kit - MBS2887857 from MyBioSource
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Two pore calcium channel protein 2, ELISA Kit - MBS2887856 from MyBioSource
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