| Gene Symbol |
TPCN2
|
| Entrez Gene |
219931
|
| Alt Symbol |
SHEP10, TPC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
two pore segment channel 2
|
| Other Description |
two pore calcium channel protein 2|two-pore calcium channel protein 2|voltage-dependent calcium channel protein TPC2
|
| Swissprots |
Q9NT82 Q8NHX9
|
| Accessions |
EAW74734 EAW74735 EAW74736 EAW74737 Q8NHX9 AB209253 BAD92490 AK023366 BAG51185 AK123089 AK298919 BAG61025 AL137479 CAB70760 AW177543 AY029200 AAK31802 BC063008 AAH63008 BP380645 CD636711 HG503921 HG503922 XM_005273824 XP_005273881 XM_005273826 XP_005273883 XM_005273827 XP_005273884 XM_005273828 XP_005273885 XM_005273830 XP_005273887 XM_005273831 XP_005273888 XM_005273832 XP_005273889 XM_006718453 XP_006718516 XM_006718454 XP_006718517 XM_006718456 XP_006718519 XM_011544802 XP_011543104 XM_011544803 XP_011543105 XM_011544804 XP_011543106 XM_011544805 XP_011543107 XM_011544806 XP_011543108 XM_011544807 XP_011543109 XM_011544808 XP_011543110 XR_247191 NM_139075 NP_620714
|
| Function |
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}.
|
| Top Pathways |
Pancreatic secretion
|
![Western Blot: Two pore calcium channel protein 2 Overexpression Lysate (Adult Normal) [NBL1-17211] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Two pore calcium channel protein 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8218_Two%2520pore%2520calcium%2520channel%2520protein%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17211-img0002.jpg)