TPCN2

Gene Symbol TPCN2
Entrez Gene 219931
Alt Symbol SHEP10, TPC2
Species Human
Gene Type protein-coding
Description two pore segment channel 2
Other Description two pore calcium channel protein 2|two-pore calcium channel protein 2|voltage-dependent calcium channel protein TPC2
Swissprots Q9NT82 Q8NHX9
Accessions EAW74734 EAW74735 EAW74736 EAW74737 Q8NHX9 AB209253 BAD92490 AK023366 BAG51185 AK123089 AK298919 BAG61025 AL137479 CAB70760 AW177543 AY029200 AAK31802 BC063008 AAH63008 BP380645 CD636711 HG503921 HG503922 XM_005273824 XP_005273881 XM_005273826 XP_005273883 XM_005273827 XP_005273884 XM_005273828 XP_005273885 XM_005273830 XP_005273887 XM_005273831 XP_005273888 XM_005273832 XP_005273889 XM_006718453 XP_006718516 XM_006718454 XP_006718517 XM_006718456 XP_006718519 XM_011544802 XP_011543104 XM_011544803 XP_011543105 XM_011544804 XP_011543106 XM_011544805 XP_011543107 XM_011544806 XP_011543108 XM_011544807 XP_011543109 XM_011544808 XP_011543110 XR_247191 NM_139075 NP_620714
Function Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}.
Subcellular Location Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}.
Top Pathways Pancreatic secretion

TPCN2 CRISPR/Cas9 KO Plasmid (h) - sc-402960 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 HDR Plasmid (h) - sc-402960-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 Double Nickase Plasmid (h) - sc-402960-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 Double Nickase Plasmid (h2) - sc-402960-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 CRISPR Activation Plasmid (h) - sc-402960-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 CRISPR Activation Plasmid (h2) - sc-402960-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 Lentiviral Activation Particles (h) - sc-402960-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 Lentiviral Activation Particles (h2) - sc-402960-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPCN2 siRNA (h) - sc-96434 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TPCN2 shRNA Plasmid (h) - sc-96434-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TPCN2 shRNA (h) Lentiviral Particles - sc-96434-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Two pore calcium channel protein 2 RNAi - H00219931-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071161 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN21858 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21858 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05290 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05290

TPCN2 siRNA (Human) - CRJ6427 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPCN2 - MBS8211068 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TPCN2 (NM_139075.3) - SHH433200 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TPCN2(NM_139075.3) - SHL088774 from Creative biogene

Category siRNA
Species Reactivities Human

TPCN2 shRNA Plasmid (Human) - CHJ6427 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TPCN2 miRNA 3'UTR clone - MiUTR1H-10661 from Creative biogene

Species Reactivities Human
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