| Gene Symbol |
KCNK4
|
| Entrez Gene |
50801
|
| Alt Symbol |
K2p4.1, TRAAK, TRAAK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, two pore domain subfamily K, member 4
|
| Other Description |
K2P4.1 potassium channel|TWIK-related arachidonic acid-stimulated potassium channel protein|potassium channel subfamily K member 4|potassium channel, subfamily K, member 4|two pore K(+) channel KT4.1|two pore K+ channel KT4.1|two pore potassium channel KT4.1
|
| Swissprots |
Q9NYG8 Q96T94 B5TJL1
|
| Accessions |
CAC93796 CAD10536 CAD10537 EAW74241 EAW74242 EAW74243 Q9NYG8 AF248242 AAG31731 AF259500 AAK49389 AK296021 BAG58791 AK307135 AK309443 BC033577 BC067791 BC110327 AAI10328 BC160128 AAI60128 DB273064 EU978935 ACH86094 NM_033310 NP_201567 NM_016611 NM_033311
|
| Function |
Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). {ECO:0000250|UniProtKB:G3V8V5, ECO:0000250|UniProtKB:O88454, ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}; Multi-pass membrane protein {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}.
|