KCNK4
| Gene Symbol | KCNK4 |
|---|---|
| Entrez Gene | 50801 |
| Alt Symbol | K2p4.1, TRAAK, TRAAK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, two pore domain subfamily K, member 4 |
| Other Description | K2P4.1 potassium channel|TWIK-related arachidonic acid-stimulated potassium channel protein|potassium channel subfamily K member 4|potassium channel, subfamily K, member 4|two pore K(+) channel KT4.1|two pore K+ channel KT4.1|two pore potassium channel KT4.1 |
| Swissprots | Q9NYG8 Q96T94 B5TJL1 |
| Accessions | CAC93796 CAD10536 CAD10537 EAW74241 EAW74242 EAW74243 Q9NYG8 AF248242 AAG31731 AF259500 AAK49389 AK296021 BAG58791 AK307135 AK309443 BC033577 BC067791 BC110327 AAI10328 BC160128 AAI60128 DB273064 EU978935 ACH86094 NM_033310 NP_201567 NM_016611 NM_033311 |
| Function | Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). {ECO:0000250|UniProtKB:G3V8V5, ECO:0000250|UniProtKB:O88454, ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}; Multi-pass membrane protein {ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}. |
TRAAK CRISPR/Cas9 KO Plasmid (h) - sc-407790 from Santa Cruz Biotechnology
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TRAAK HDR Plasmid (h) - sc-407790-HDR from Santa Cruz Biotechnology
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TRAAK Double Nickase Plasmid (h) - sc-407790-NIC from Santa Cruz Biotechnology
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TRAAK Double Nickase Plasmid (h2) - sc-407790-NIC-2 from Santa Cruz Biotechnology
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TRAAK CRISPR Activation Plasmid (h) - sc-407790-ACT from Santa Cruz Biotechnology
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TRAAK CRISPR Activation Plasmid (h2) - sc-407790-ACT-2 from Santa Cruz Biotechnology
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TRAAK Lentiviral Activation Particles (h) - sc-407790-LAC from Santa Cruz Biotechnology
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TRAAK Lentiviral Activation Particles (h2) - sc-407790-LAC-2 from Santa Cruz Biotechnology
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TRAAK siRNA (h) - sc-42345 from Santa Cruz Biotechnology
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TRAAK shRNA Plasmid (h) - sc-42345-SH from Santa Cruz Biotechnology
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TRAAK shRNA (h) Lentiviral Particles - sc-42345-V from Santa Cruz Biotechnology
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KCNK4 RNAi - H00050801-R02 from Novus Biologicals
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KCNK4 RNAi - H00050801-R03 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10972 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10972 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01743 from Sigma-Aldrich
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KCNK4 siRNA (Human) - CRH9403 from Cohesion Biosciences
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KCNK4 RNAi - H00050801-R01 from Novus Biologicals
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shRNA set against Human KCNK4 (NM_033310.2) - SHH323471 from Creative biogene
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shRNA set against Human KCNK4(NM_033310.2) - SHL190308 from Creative biogene
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Human KCNK4 siRNA - orb269905 from Biorbyt
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KCNK4 shRNA Plasmid (Human) - CHH9403 from Cohesion Biosciences
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KCNK4 miRNA 3'UTR clone - MiUTR1H-05147 from Creative biogene
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