EXOSC2

Gene Symbol EXOSC2
Entrez Gene 23404
Alt Symbol RRP4, Rrp4p, hRrp4p, p7
Species Human
Gene Type protein-coding
Description exosome component 2
Other Description exosome complex component RRP4|exosome complex exonuclease RRP4|homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)|homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease|ribosomal RNA-processing protein 4
Swissprots Q13868 B4DKK6 A3KFL3 Q9NUY4
Accessions AAB60392 EAW87941 EAW87942 EAW87943 EAW87944 Q13868 AK001916 BAA91977 AK022460 BAB14043 AK090512 BAG52174 AK092727 AK296605 BAG59218 AK303163 BAG64263 AL573310 BC000747 AAH00747 BC128445 AAI28446 BU934039 CB112633 DA813307 DQ892753 ABM83679 EU176744 ABW03545 XM_005272176 XP_005272233 XM_006717022 XP_006717085 XM_006717023 XP_006717086 XM_006717024 XP_006717087 NM_001282708 NP_001269637 NM_001282709 NP_001269638 NM_014285 NP_055100 NR_104230
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus.
Top Pathways RNA degradation

EXOSC2 (E-12) - sc-104919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EXOSC2 (E-12): sc-104919. Western blot analysis of EXOSC2 expression in Jurkat (A) and Hep G2 (B) whole cell lysates and HeLa (C) and Jurkat (D) nuclear extracts.

EXOSC2 (2334C3a) - sc-81085 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EXOSC2 (2334C3a): sc-81085 Western Blot analysis of human recombinant EXOSC2 fusion protein.

Anti-RRP4 antibody [EPR13605] - N-terminal - ab181211 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13605
Western blot analysis of immunoprecipitation pellet from 293 cell lysate immunoprecipitated using ab181211 at 1/50 dilution.Secondary: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution.

Anti-RRP4 antibody [EPR13606(B)] - C-terminal - ab185235 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13606(B)
All lanes : Anti-RRP4 antibody [EPR13606(B)] - C-terminal (ab185235) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : HeLa cell lysateLane 3 : 293 cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-EXOSC2 / RRP4 Antibody - LS-C128903 from LifeSpan Bioscience

Prices $755.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EXOSC2 / RRP4 Antibody - LS-C65796 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-EXOSC2 / RRP4 Antibody (N-Terminus) - LS-C30712 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
B: Jurkat Cell Lysate

Anti-EXOSC2 / RRP4 Antibody (clone 2334C3a) - LS-C184475 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2334C3a

Anti-EXOSC2 / RRP4 Antibody (clone 15B3) - LS-C202649 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 15B3

Anti-EXOSC2 / RRP4 Antibody (aa143-192) - LS-C101870 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EXOSC2 / RRP4 antibody LS-C101870 Western blot of HepG2 cell lysate.

Anti-EXOSC2 / RRP4 Antibody (aa71-161) - LS-C307453 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EXOSC2 / RRP4 Antibody (clone 2334C3a) - LS-C342515 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2334C3a
Western blot analysis of immunized recombinant protein, using anti-EXOSC2 monoclonal antibody.

Anti-EXOSC2 / RRP4 Antibody (aa243-293) - LS-C290534 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EXOSC2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-EXOSC2 antibody used for IP at 6 ug/mg lysate. EXOSC2 was also immunoprecipitated by rabbit anti-EXOSC2 antibody BL14001. For blotting immunoprecipitated EXOSC2, was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-EXOSC2 / RRP4 Antibody (aa1-30) - LS-C344188 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
EXOSC2 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The EXOSC2 antibody detected the EXOSC2 protein (arrow).

RRP4 Antibody - NBP2-20235 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RRP4 Antibody - NBP2-22240 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RRP4 Antibody - NBP2-32330 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

RRP4 Antibody - H00023404-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RRP4 Antibody [H00023404-A01] - EXOSC2 polyclonal antibody (A01), Lot # ABNOVA060711QCS1 Western Blot analysis of EXOSC2 expression in A-431 ( Cat # L015V1 ).

RRP4 Antibody (4B6) - H00023404-M06 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 4B6
ELISA: RRP4 Antibody (4B6) [H00023404-M06] - Detection limit for recombinant GST tagged EXOSC2 is approximately 0.1ng/ml as a capture antibody.

Anti-EXOSC2 antibody produced in rabbit - SAB2100731 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-EXOSC2: <B>Cat. No.SAB2100731</B>: EXOSC2 in HepG2 cell lysate with EXOSC2 antibody at 1.0 μg/mL.

Anti-EXOSC2 antibody produced in rabbit - AV40762 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV40762</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat

Anti-EXOSC2 antibody produced in rabbit - SAB4200396 from Sigma-Aldrich

Prices $343.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell line lysates were separated on SDS-PAGE and probed with 2.5 μg/mL Rabbit Anti-EXOSC2 (<B>Cat. No. SAB4200396</B>). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. HEK-293T overexpressing human EXOSC2<BR/>2. HeLa <BR/>3. JURKAT<BR/>4. MDA-MB-231<BR/>5. CHO<BR/>6. A20<BR/>7. AT3B1

Anti-EXOSC2 antibody produced in rabbit - HPA021790 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EXOSC2: <B>Cat. No. HPA021790</B>: Immunohistochemical staining of human kidney shows strong positivity in tubules.

EXOSC2 antibody - middle region (ARP40761_P050) - ARP40761_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EXOSC2 antibody - N-terminal region (ARP40762_T100) - ARP40762_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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