EXOSC2

Gene Symbol	EXOSC2
Entrez Gene	23404
Alt Symbol	RRP4, Rrp4p, hRrp4p, p7
Species	Human
Gene Type	protein-coding
Description	exosome component 2
Other Description	exosome complex component RRP4|exosome complex exonuclease RRP4|homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)|homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease|ribosomal RNA-processing protein 4
Swissprots	Q13868 B4DKK6 A3KFL3 Q9NUY4
Accessions	AAB60392 EAW87941 EAW87942 EAW87943 EAW87944 Q13868 AK001916 BAA91977 AK022460 BAB14043 AK090512 BAG52174 AK092727 AK296605 BAG59218 AK303163 BAG64263 AL573310 BC000747 AAH00747 BC128445 AAI28446 BU934039 CB112633 DA813307 DQ892753 ABM83679 EU176744 ABW03545 XM_005272176 XP_005272233 XM_006717022 XP_006717085 XM_006717023 XP_006717086 XM_006717024 XP_006717087 NM_001282708 NP_001269637 NM_001282709 NP_001269638 NM_014285 NP_055100 NR_104230
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EXOSC2 / RRP4 Antibody Blocking Peptide - LS-E14939 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC2 / RRP4 Antibody Blocking Peptide - LS-E14940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RRP4 Protein - H00023404-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EXOSC2 Blocking Peptide - 33R-8007 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC2 Blocking Peptide - 33R-1154 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RRP4 / EXOSC2 - H00023404-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RRP4 / EXOSC2 - H00023404-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXOSC2 fusion protein - Ag7003 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EXOSC2 fusion protein - Ag6525 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EXOSC2, His-tagged - EXOSC2-12595H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Exosome Component 2 (EXOSC2) - RPH822Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP4(EXOSC2) - CSB-YP613428HU CSB-EP613428HU CSB-BP613428HU CSB-MP613428HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RRP4 / EXOSC2 - TP300753 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RRP4 Protein - NBP1-92355PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

EXOSC2-Blocking-PeptideN-term - BP20534a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC2 Peptide, Human - M34GP05142H from Creative Peptides Category Peptide Source Synthetic. Species Human

RRP4 Recombinant Protein Antigen - NBP2-58481PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exosome complex component RRP4 (EXOSC2), Recombinant Protein - MBS1475607 from MyBioSource Category Protein Prices $1,050.00, $1,050.00, $1,280.00, $1,280.00, $1,630.00, $1,630.00, $2,095.00, $2,095.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Protein P7, Recombinant Protein - MBS7037738 from MyBioSource Category Protein Prices $925.00, $1,905.00, $3,115.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

Protein P7, Recombinant Protein - MBS1089857 from MyBioSource Category Protein Prices $1,275.00, $1,275.00, $1,495.00, $1,495.00, $2,085.00, $2,085.00, $2,550.00, $2,550.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein P7, Recombinant Protein - MBS1462500 from MyBioSource Category Protein Prices $930.00, $930.00, $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,840.00, $1,840.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein P7 (ORF12), Recombinant Protein - MBS1247245 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

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