EXOSC2
| Gene Symbol | EXOSC2 |
|---|---|
| Entrez Gene | 23404 |
| Alt Symbol | RRP4, Rrp4p, hRrp4p, p7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 2 |
| Other Description | exosome complex component RRP4|exosome complex exonuclease RRP4|homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)|homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease|ribosomal RNA-processing protein 4 |
| Swissprots | Q13868 B4DKK6 A3KFL3 Q9NUY4 |
| Accessions | AAB60392 EAW87941 EAW87942 EAW87943 EAW87944 Q13868 AK001916 BAA91977 AK022460 BAB14043 AK090512 BAG52174 AK092727 AK296605 BAG59218 AK303163 BAG64263 AL573310 BC000747 AAH00747 BC128445 AAI28446 BU934039 CB112633 DA813307 DQ892753 ABM83679 EU176744 ABW03545 XM_005272176 XP_005272233 XM_006717022 XP_006717085 XM_006717023 XP_006717086 XM_006717024 XP_006717087 NM_001282708 NP_001269637 NM_001282709 NP_001269638 NM_014285 NP_055100 NR_104230 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus. |
| Top Pathways | RNA degradation |
EXOSC2 CRISPR/Cas9 KO Plasmid (h) - sc-408843 from Santa Cruz Biotechnology
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EXOSC2 HDR Plasmid (h) - sc-408843-HDR from Santa Cruz Biotechnology
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EXOSC2 Double Nickase Plasmid (h) - sc-408843-NIC from Santa Cruz Biotechnology
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EXOSC2 Double Nickase Plasmid (h2) - sc-408843-NIC-2 from Santa Cruz Biotechnology
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EXOSC2 CRISPR Activation Plasmid (h) - sc-408843-ACT from Santa Cruz Biotechnology
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EXOSC2 CRISPR Activation Plasmid (h2) - sc-408843-ACT-2 from Santa Cruz Biotechnology
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EXOSC2 Lentiviral Activation Particles (h) - sc-408843-LAC from Santa Cruz Biotechnology
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EXOSC2 Lentiviral Activation Particles (h2) - sc-408843-LAC-2 from Santa Cruz Biotechnology
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EXOSC2 siRNA (h) - sc-92604 from Santa Cruz Biotechnology
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EXOSC2 shRNA Plasmid (h) - sc-92604-SH from Santa Cruz Biotechnology
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EXOSC2 shRNA (h) Lentiviral Particles - sc-92604-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU028461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8047 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8047 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12512 from Sigma-Aldrich
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EXOSC2 siRNA (Human) - CRH8244 from Cohesion Biosciences
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RRP4 RNAi - H00023404-R01 from Novus Biologicals
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EXOSC2 - MBS8226465 from MyBioSource
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shRNA set against Human EXOSC2 (NM_014285.5) - SHH288093 from Creative biogene
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Human EXOSC2 siRNA - orb268746 from Biorbyt
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EXOSC2 shRNA Plasmid (Human) - CHH8244 from Cohesion Biosciences
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EXOSC2 miRNA 3'UTR clone - MiUTR3H-04806 from Creative biogene
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