RNF144B

Gene Symbol	RNF144B
Entrez Gene	255488
Alt Symbol	IBRDC2, PIR2, bA528A10.3, p53RFP
Species	Human
Gene Type	protein-coding
Description	ring finger protein 144B
Other Description	E3 ubiquitin-protein ligase RNF144B|IBR domain containing 2|IBR domain-containing protein 2|p53-inducible RING finger protein
Swissprots	Q8N3R7 B3KUA8 Q7Z419 Q9BX38 Q6P4Q0 Q5TB85 B4DZI2
Accessions	EAW55406 EAW55407 EAW55408 EAW55409 EAW55410 Q7Z419 AB076367 BAC02434 AJ420555 AK096832 BAG53370 AK302935 BAG64094 AL832329 CAD38622 BC063311 AAH63311 EU832137 ACE87487 EU832230 ACE86800 HQ448042 ADQ32523 XM_005248984 XP_005249041 XM_005248986 XP_005249043 NM_182757 NP_877434
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269|PubMed:12853982, ECO:0000269|PubMed:20300062}.
Subcellular Location	Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Tissue Specificity	Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269|PubMed:16427630, ECO:0000269|PubMed:20300062}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

p53RFP/IBRDC2 (L-15) - sc-33017 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p53RFP/IBRDC2 (H-75) - sc-67014 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

p53RFP/IBRDC2 (E-20) - sc-33015 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p53RFP/IBRDC2 (M-65) - sc-67015 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

p53RFP (U-16) - sc-101247 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-IBRDC2 antibody - ab57246 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-IBRDC2 antibody - ab138423 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-IBRDC2 antibody - ab106327 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-IBRDC2 antibody [4F1] - ab110458 from Abcam Prices $464.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4F1

Anti-IBRDC2 antibody [6B11] - ab114013 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6B11

Anti-IBRDC2 antibody - N-terminal - ab197995 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (clone 4F1) IHC-plus™ - LS-B4550 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4F1

Anti-RNF144B Antibody (clone 3D7) - LS-C114792 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3D7

Anti-RNF144B Antibody (clone 9H10) - LS-C114790 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9H10

Anti-RNF144B Antibody (aa215-264) - LS-C110790 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (clone 1E1) - LS-C114796 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E1

Anti-RNF144B Antibody (aa90-118, AP) - LS-C240087 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (aa90-118, FITC) - LS-C240088 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (aa90-118, APC) - LS-C240089 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (aa90-118, Biotin) - LS-C240090 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (aa90-118, PE) - LS-C240095 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (clone 7H2) - LS-C114785 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7H2

Anti-RNF144B Antibody (clone 12B6) - LS-C114793 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 12B6

Anti-RNF144B Antibody (aa90-118, Azide-free, HRP) - LS-C248020 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF144B Antibody (aa89-118) - LS-C324726 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Search more