RNF144B

Gene Symbol RNF144B
Entrez Gene 255488
Alt Symbol IBRDC2, PIR2, bA528A10.3, p53RFP
Species Human
Gene Type protein-coding
Description ring finger protein 144B
Other Description E3 ubiquitin-protein ligase RNF144B|IBR domain containing 2|IBR domain-containing protein 2|p53-inducible RING finger protein
Swissprots Q8N3R7 B3KUA8 Q7Z419 Q9BX38 Q6P4Q0 Q5TB85 B4DZI2
Accessions EAW55406 EAW55407 EAW55408 EAW55409 EAW55410 Q7Z419 AB076367 BAC02434 AJ420555 AK096832 BAG53370 AK302935 BAG64094 AL832329 CAD38622 BC063311 AAH63311 EU832137 ACE87487 EU832230 ACE86800 HQ448042 ADQ32523 XM_005248984 XP_005249041 XM_005248986 XP_005249043 NM_182757 NP_877434
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269|PubMed:12853982, ECO:0000269|PubMed:20300062}.
Subcellular Location Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Tissue Specificity Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269|PubMed:16427630, ECO:0000269|PubMed:20300062}.

RNF144B-Over-expression-Lysate - LY10554a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag RNF144B (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RNF144B gene

IBRDC2 293T Cell Transient Overexpression Lysate(Denatured) - H00255488-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

RNF144B overexpression lysate - LY405351 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

RNF144B 293 Cell Lysate - 403579 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

IBRDC2 Overexpression Lysate (Denatured) - H00255488-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

IBRDC2 Overexpression Lysate (Native) - NBL1-15428 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: IBRDC2 Overexpression Lysate (Adult Normal) [NBL1-15428] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IBRDC2.

RNF144B Over-expression Lysate Product - GWB-4648E1 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human RNF144B Knockdown Stable Cell Line - CSC-DC013389 from Creative biogene

Category Cell Line
Species Human
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