RNF144B

Gene Symbol RNF144B
Entrez Gene 255488
Alt Symbol IBRDC2, PIR2, bA528A10.3, p53RFP
Species Human
Gene Type protein-coding
Description ring finger protein 144B
Other Description E3 ubiquitin-protein ligase RNF144B|IBR domain containing 2|IBR domain-containing protein 2|p53-inducible RING finger protein
Swissprots Q8N3R7 B3KUA8 Q7Z419 Q9BX38 Q6P4Q0 Q5TB85 B4DZI2
Accessions EAW55406 EAW55407 EAW55408 EAW55409 EAW55410 Q7Z419 AB076367 BAC02434 AJ420555 AK096832 BAG53370 AK302935 BAG64094 AL832329 CAD38622 BC063311 AAH63311 EU832137 ACE87487 EU832230 ACE86800 HQ448042 ADQ32523 XM_005248984 XP_005249041 XM_005248986 XP_005249043 NM_182757 NP_877434
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269|PubMed:12853982, ECO:0000269|PubMed:20300062}.
Subcellular Location Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Tissue Specificity Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269|PubMed:16427630, ECO:0000269|PubMed:20300062}.

p53RFP CRISPR/Cas9 KO Plasmid (h) - sc-406081 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP HDR Plasmid (h) - sc-406081-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP Double Nickase Plasmid (h) - sc-406081-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP Double Nickase Plasmid (h2) - sc-406081-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP CRISPR Activation Plasmid (h) - sc-406081-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP CRISPR Activation Plasmid (h2) - sc-406081-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP Lentiviral Activation Particles (h) - sc-406081-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP Lentiviral Activation Particles (h2) - sc-406081-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53RFP siRNA (h) - sc-44824 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p53RFP shRNA Plasmid (h) - sc-44824-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p53RFP shRNA (h) Lentiviral Particles - sc-44824-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IBRDC2 RNAi - H00255488-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU077511 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18388 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18388 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR14091 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr14091

RNF144B siRNA (Human) - CRJ6723 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF144B - MBS829015 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF144B (NM_182757.3) - SHH396784 from Creative biogene

Category siRNA
Species Reactivities Human

RNF144B shRNA Plasmid (Human) - CHJ6723 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF144B miRNA 3'UTR clone - MiUTR1H-04772 from Creative biogene

Species Reactivities Human
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