RNF144B

Gene Symbol	RNF144B
Entrez Gene	255488
Alt Symbol	IBRDC2, PIR2, bA528A10.3, p53RFP
Species	Human
Gene Type	protein-coding
Description	ring finger protein 144B
Other Description	E3 ubiquitin-protein ligase RNF144B|IBR domain containing 2|IBR domain-containing protein 2|p53-inducible RING finger protein
Swissprots	Q8N3R7 B3KUA8 Q7Z419 Q9BX38 Q6P4Q0 Q5TB85 B4DZI2
Accessions	EAW55406 EAW55407 EAW55408 EAW55409 EAW55410 Q7Z419 AB076367 BAC02434 AJ420555 AK096832 BAG53370 AK302935 BAG64094 AL832329 CAD38622 BC063311 AAH63311 EU832137 ACE87487 EU832230 ACE86800 HQ448042 ADQ32523 XM_005248984 XP_005249041 XM_005248986 XP_005249043 NM_182757 NP_877434
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269|PubMed:12853982, ECO:0000269|PubMed:20300062}.
Subcellular Location	Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Tissue Specificity	Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269|PubMed:16427630, ECO:0000269|PubMed:20300062}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IBRDC2 full length protein - ab166048 from Abcam Category Protein Source Wheat germ Species Human

Human IBRDC2 protein fragment - ab166049 from Abcam Category Protein Source Wheat germ Species Human

RNF144B Antibody Blocking Peptide - LS-E6011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF144B Antibody Blocking Peptide - LS-E16000 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IBRDC2 Protein - H00255488-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IBRDC2 Partial Recombinant Protein - H00255488-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RNF144B-Antibody-Center-Blocking-Peptide - BP18585c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF144B Blocking Peptide - 33R-4424 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF144B - H00255488-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF144B - H00255488-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF144B - H00255488-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF144B - H00255488-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF144B fusion protein - Ag24635 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

IBRDC2 Protein - NBP2-37941PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RNF144B Peptide, Human - M34GP13389H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF144B fusion protein - Ag23679 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

E3 ubiquitin-protein ligase RNF144B (RNF144B), Recombinant Protein - MBS7028735 from MyBioSource Category Protein Prices $1,115.00, $2,100.00, $3,310.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Search more