| Gene Symbol |
EXOSC1
|
| Entrez Gene |
51013
|
| Alt Symbol |
CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exosome component 1
|
| Other Description |
3'-5' exoribonuclease CSL4 homolog|CSL4 exosomal core protein homolog|exosomal core protein CSL4|exosome complex component CSL4|homolog of yeast exosomal core protein CSL4
|
| Swissprots |
B2R9B3 Q5JTH3 Q9Y3B2
|
| Accessions |
EAW49936 Q9Y3B2 AF151866 AAD34103 AK091709 AK307229 AK313717 BAG36460 BC012538 BC022067 AAH22067 DB137484 JF432281 ADZ15498 XM_011539845 XP_011538147 XM_011539846 XP_011538148 XM_011539847 XP_011538149 XR_246092 XR_945768 NM_016046 NP_057130
|
| Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}.
|
| Top Pathways |
RNA degradation
|