EXOSC1

Gene Symbol EXOSC1
Entrez Gene 51013
Alt Symbol CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13
Species Human
Gene Type protein-coding
Description exosome component 1
Other Description 3'-5' exoribonuclease CSL4 homolog|CSL4 exosomal core protein homolog|exosomal core protein CSL4|exosome complex component CSL4|homolog of yeast exosomal core protein CSL4
Swissprots B2R9B3 Q5JTH3 Q9Y3B2
Accessions EAW49936 Q9Y3B2 AF151866 AAD34103 AK091709 AK307229 AK313717 BAG36460 BC012538 BC022067 AAH22067 DB137484 JF432281 ADZ15498 XM_011539845 XP_011538147 XM_011539846 XP_011538148 XM_011539847 XP_011538149 XR_246092 XR_945768 NM_016046 NP_057130
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}.
Top Pathways RNA degradation

EXOSC1 CRISPR/Cas9 KO Plasmid (h) - sc-412088 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 HDR Plasmid (h) - sc-412088-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 Double Nickase Plasmid (h) - sc-412088-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 Double Nickase Plasmid (h2) - sc-412088-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 CRISPR Activation Plasmid (h) - sc-412088-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 CRISPR Activation Plasmid (h2) - sc-412088-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 Lentiviral Activation Particles (h) - sc-412088-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 Lentiviral Activation Particles (h2) - sc-412088-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC1 siRNA (h) - sc-90451 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC1 shRNA Plasmid (h) - sc-90451-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC1 shRNA (h) Lentiviral Particles - sc-90451-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exosome component 1 RNAi - H00051013-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8045 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8045 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04022 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04022

EXOSC1 siRNA (Human) - CRH9454 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXOSC1 - MBS8200719 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EXOSC1 (NM_016046.3) - SHH288077 from Creative biogene

Category siRNA
Species Reactivities Human

EXOSC1 shRNA Plasmid (Human) - CHH9454 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXOSC1 miRNA 3'UTR clone - MiUTR1H-03344 from Creative biogene

Species Reactivities Human
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