EXOSC1

Gene Symbol	EXOSC1
Entrez Gene	51013
Alt Symbol	CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13
Species	Human
Gene Type	protein-coding
Description	exosome component 1
Other Description	3'-5' exoribonuclease CSL4 homolog\|CSL4 exosomal core protein homolog\|exosomal core protein CSL4\|exosome complex component CSL4\|homolog of yeast exosomal core protein CSL4
Swissprots	B2R9B3 Q5JTH3 Q9Y3B2
Accessions	EAW49936 Q9Y3B2 AF151866 AAD34103 AK091709 AK307229 AK313717 BAG36460 BC012538 BC022067 AAH22067 DB137484 JF432281 ADZ15498 XM_011539845 XP_011538147 XM_011539846 XP_011538148 XM_011539847 XP_011538149 XR_246092 XR_945768 NM_016046 NP_057130
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269\|PubMed:11812149}. Nucleus {ECO:0000305\|PubMed:11812149}. Cytoplasm {ECO:0000305\|PubMed:11812149}.
Top Pathways	RNA degradation

Anti-EXOSC1 antibody - ab156688 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-EXOSC1 antibody (ab156688) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-EXOSC1 antibody - ab167179 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-EXOSC1 antibody (ab167179) at 1/500 dilutionLane 1 : EXOSC1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-EXOSC1 antibody - ab67011 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-EXOSC1 antibody (ab67011) at 1/1000 dilutionLane 1 : EXOSC1 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysate

Anti-EXOSC1 antibody [EPR13525] - ab181167 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13525

All lanes : Anti-EXOSC1 antibody [EPR13525] (ab181167) at 1/2000 dilutionLane 1 : 293T lysateLane 2 : Jurkat lysateLane 3 : HepG2 lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-EXOSC1 antibody [EPR13526] - ab181108 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13526

All lanes : Anti-EXOSC1 antibody [EPR13526] (ab181108) at 1/2000 dilutionLane 1 : K562 cell lysateLane 2 : C6 cell lysateLane 3 : Raw264.7 cell lysateLane 4 : PC-12 cell lysateLane 5 : NIH/3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-EXOSC1 antibody - C-terminal - ab174158 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 antibody - C-terminal (ab174158) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-p13 antibody [BM3] - ab1044 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	BM3

Anti-EXOSC1 / CSL4 Antibody - LS-C91133 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, APC) - LS-C214056 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, AP) - LS-C214055 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, FITC) - LS-C214058 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, Biotin) - LS-C214057 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, Azide-free, HRP) - LS-C214059 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (aa165-191, PE) - LS-C214060 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody - LS-C307450 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody - LS-C307452 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-EXOSC1 / CSL4 Antibody (aa164-191) - LS-C321228 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXOSC1 / CSL4 Antibody (clone 1H8) - LS-C340518 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H8

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EXOSC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EXOSC1 (1:2000).

Anti-EXOSC1 / CSL4 Antibody (aa165-191) - LS-C159577 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

EXOSC1 Antibody western blot of 293 cell line lysates (35 ug/lane). The EXOSC1 Antibody detected the EXOSC1 protein (arrow).

Anti-EXOSC1 / CSL4 Antibody (aa145-195) - LS-C290532 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human EXOSC1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-EXOSC1 antibody used for IP at 6 ug/mg lysate. EXOSC1 was also immunoprecipitated by rabbit anti-EXOSC1 antibody BL13999. For blotting immunoprecipitated EXOSC1, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Exosome component 1 Antibody - NBP1-84523 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: Exosome component 1 Antibody [NBP1-84523] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli.

Exosome component 1 Antibody - NBP2-22239 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Exosome component 1 Antibody [NBP2-22239] - Whole cell lysate (15 and 50 ug) from mouse NIH3T3 cells. NBP2-22239 used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Exosome component 1 Antibody - H00051013-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Exosome component 1 Antibody - H00051013-B02P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: Exosome component 1 Antibody [H00051013-B02P] - Analysis of EXOSC1 expression in transfected 293T cell line by EXOSC1 polyclonal antibody. Lane 1: EXOSC1 transfected lysate(21.45 KDa). Lane 2: Non-transfected lysate.

Exosome component 1 Antibody - H00051013-B02 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Exosome component 1 Antibody [H00051013-B02] - analysis of EXOSC1 expression in transfected 293T cell line by EXOSC1 MaxPab polyclonal antibody (B02). Lane 1: EXOSC1 transfected lysate (21.50 KDa). Lane 2: Non-transfected lysate.

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