EXOSC1

Gene Symbol	EXOSC1
Entrez Gene	51013
Alt Symbol	CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13
Species	Human
Gene Type	protein-coding
Description	exosome component 1
Other Description	3'-5' exoribonuclease CSL4 homolog|CSL4 exosomal core protein homolog|exosomal core protein CSL4|exosome complex component CSL4|homolog of yeast exosomal core protein CSL4
Swissprots	B2R9B3 Q5JTH3 Q9Y3B2
Accessions	EAW49936 Q9Y3B2 AF151866 AAD34103 AK091709 AK307229 AK313717 BAG36460 BC012538 BC022067 AAH22067 DB137484 JF432281 ADZ15498 XM_011539845 XP_011538147 XM_011539846 XP_011538148 XM_011539847 XP_011538149 XR_246092 XR_945768 NM_016046 NP_057130
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC1 full length protein - ab162391 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC1 full length protein - ab181892 from Abcam Category Protein Source E. coli Species Human

EXOSC1 / CSL4 Antibody Blocking Peptide - LS-E5889 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exosome component 1 Recombinant Protein - H00051013-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

EXOSC1-Antibody-C-term-Blocking-Peptide - BP18442b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC1 protein (His tag) - 80R-3856 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

EXOSC1 (1-195, His-tag) - AR51543PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

EXOSC1 (1-195, His-tag) - AR51543PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

EXOSC1 - H00051013-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

EXOSC1 - H00051013-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EXOSC1 - H00051013-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXOSC1, 1-195aa, Human, His tag, E.coli - 01-P2723 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

EXOSC1 fusion protein - Ag3286 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EXOSC1, GST-tagged - EXOSC1-12593H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EXOSC1, His-tagged - EXOSC1-230H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component CSL4(EXOSC1) - CSB-YP897103HU CSB-EP897103HU CSB-BP897103HU CSB-MP897103HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC1, 1-195aa, Human, His tag, E.coli - ATGP2723 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

EXOSC1 - TP306007 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human EXOSC1 protein - orb259886 from Biorbyt Category Protein Prices $170.00, $289.00, $1,122.00 Sizes 2 μg, 10 μg, 100 μg Species Human

Exosome component 1 Recombinant Protein Antigen - NBP1-84523PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exosome Component 1 Protein (Recombinant) - abx263423 from Abbexa Category Protein

EXOSC1 Peptide, Human - M34GP05140H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Exosome component 1 Protein - NBP2-51735 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 20 µg, 100 µg Source E. coli Species Human

EXOSC1 - PAT-82722-1 from Nordic BioSite Category Protein Species Human

EXOSC1 - PAT-82722-2 from Nordic BioSite Category Protein Species Human

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