| Gene Symbol |
RASIP1
|
| Entrez Gene |
54922
|
| Alt Symbol |
RAIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras interacting protein 1
|
| Other Description |
ras-interacting protein 1
|
| Swissprots |
Q6U676 Q5U651
|
| Accessions |
EAW52393 EAW52394 Q5U651 AK000408 BAA91145 AK123179 BAG53877 AY378097 AAR24580 BC021860 AAH21860 BC028614 AAH28614 BC042111 AAH42111 BX389914 XM_011527053 XP_011525355 XM_011527054 XP_011525356 XM_011527055 XP_011525357 XR_935837 NM_017805 NP_060275
|
| Function |
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:15031288}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15031288}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
|
| Tissue Specificity |
Highly expressed in heart. Detected at lower levels in placenta and pancreas. {ECO:0000269|PubMed:15031288}.
|