LAMTOR5

Gene Symbol	LAMTOR5
Entrez Gene	10542
Alt Symbol	HBXIP, XIP
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Other Description	HBV X-interacting protein|HBx-interacting protein|hepatitis B virus x interacting protein|hepatitis B virus x-interacting protein (9.6kD)|late endosomal/lysosomal adaptor and MAPK and MTOR activator 5|ragulator complex protein LAMTOR5
Swissprots	Q6IBD8 O43504
Accessions	EAW56447 O43504 AA443738 AF029890 AAC52032 AK054769 AK056679 BAG51783 AY623819 AAV30683 BC062619 AAH62619 BX092018 CR456866 CAG33147 CR542130 CAG46927 HQ257924 ADR82678 NM_006402 NP_006393
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980}.
Subcellular Location	Cytoplasm. Lysosome.
Tissue Specificity	Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HBXIP full length protein - ab130038 from Abcam Category Protein Source E. coli Species Human

HBXIP Recombinant Protein - H00010542-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HBXIP Protein - NBP1-98882 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

HBXIP Protein - GTX111009-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human HBXIP protein - orb168477 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E. coli Species Human

HBXIP Blocking Peptide - 33R-2632 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HBXIP protein (His tag) - 80R-2393 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

HBX-interacting protein / XIP (1-173, His-tag) - AR50474PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

HBX-interacting protein / XIP (1-173, His-tag) - AR50474PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

HBX-interacting protein / XIP - H00010542-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HBX-interacting protein / XIP - H00010542-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HBXIP, 1-173aa Human, His tag, E.coli - 01-P1650 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

HBXIP fusion protein - Ag5894 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

HBXIP fusion protein - Ag6000 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

HBXIP Human - HBPS-242 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Hepatitis B Virus x Interacting Protein - BP002834-HBV-235 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

HBXIP, 1-173aa Human, His tag, E.coli - GWB-P0388K from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

HBV X - GWB-B492AF from Genway Biotech Category Protein Prices $75.00, $165.00, $4,805.00 Sizes 5 μg, 25 μg, 1000 μg

Recombinant Human Hepatitis B Virus X Interacting Protein, His-tagged - HBXIP-6961H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human HBXIP, GST-tagged - HBXIP-13689H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human LAMTOR5 - LAMTOR5-890H from Creative Biomart Category Protein Source Mammalian Cells Species Human

HBV X - PGB-22136-2 from Nordic BioSite Category Protein

Recombinant Human Hepatitis B virus X-interacting protein(HBXIP) - CSB-YP010161HU CSB-EP010161HU CSB-BP010161HU CSB-MP010161HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HBXIP, 1-173aa, Human, His tag, E.coli - ATGP1650 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

LAMTOR5 Protein - abx163638 from Abbexa Category Protein Species Human, Mouse, Rat

Search more