LAMTOR5

Gene Symbol LAMTOR5
Entrez Gene 10542
Alt Symbol HBXIP, XIP
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Other Description HBV X-interacting protein|HBx-interacting protein|hepatitis B virus x interacting protein|hepatitis B virus x-interacting protein (9.6kD)|late endosomal/lysosomal adaptor and MAPK and MTOR activator 5|ragulator complex protein LAMTOR5
Swissprots Q6IBD8 O43504
Accessions EAW56447 O43504 AA443738 AF029890 AAC52032 AK054769 AK056679 BAG51783 AY623819 AAV30683 BC062619 AAH62619 BX092018 CR456866 CAG33147 CR542130 CAG46927 HQ257924 ADR82678 NM_006402 NP_006393
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980}.
Subcellular Location Cytoplasm. Lysosome.
Tissue Specificity Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

HBXIP CRISPR/Cas9 KO Plasmid (h) - sc-405228 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP HDR Plasmid (h) - sc-405228-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP Double Nickase Plasmid (h) - sc-405228-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP Double Nickase Plasmid (h2) - sc-405228-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP CRISPR Activation Plasmid (h) - sc-405228-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP CRISPR Activation Plasmid (h2) - sc-405228-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP Lentiviral Activation Particles (h) - sc-405228-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP Lentiviral Activation Particles (h2) - sc-405228-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HBXIP siRNA (h) - sc-72289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HBXIP shRNA Plasmid (h) - sc-72289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HBXIP shRNA (h) Lentiviral Particles - sc-72289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HBXIP RNAi - H00010542-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU109361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9908 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9908 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02332 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02332

LAMTOR5 siRNA (Human) - CRH7167 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HBXIP (NM_006402.2) - SHH310685 from Creative biogene

Category siRNA
Species Reactivities Human

LAMTOR5 shRNA Plasmid (Human) - CHH7167 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LAMTOR5 miRNA 3'UTR clone - MiUTR1H-04392 from Creative biogene

Species Reactivities Human
Search more