LAMTOR5

Gene Symbol LAMTOR5
Entrez Gene 10542
Alt Symbol HBXIP, XIP
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Other Description HBV X-interacting protein|HBx-interacting protein|hepatitis B virus x interacting protein|hepatitis B virus x-interacting protein (9.6kD)|late endosomal/lysosomal adaptor and MAPK and MTOR activator 5|ragulator complex protein LAMTOR5
Swissprots Q6IBD8 O43504
Accessions EAW56447 O43504 AA443738 AF029890 AAC52032 AK054769 AK056679 BAG51783 AY623819 AAV30683 BC062619 AAH62619 BX092018 CR456866 CAG33147 CR542130 CAG46927 HQ257924 ADR82678 NM_006402 NP_006393
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980}.
Subcellular Location Cytoplasm. Lysosome.
Tissue Specificity Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

LAMTOR5/HBXIP (D4V4S) Rabbit mAb - 14633 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4V4S
Western blot analysis of extracts from various cell lines using LAMTOR5/HBXIP (D4V4S) Rabbit mAb.

HBXIP (H-5) - sc-373980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HBXIP (H-5): sc-373980. Western blot analysis of HBXIP expression in non-transfected: sc-117752 (A) and human HBXIP transfected: sc-116745 (B) 293T whole cell lysates.

HBXIP (C-16) - sc-54080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HBXIP (C-16): sc-54080. Western blot analysis of HBXIP expression in rat spleen (A) and mouse heart (B) tissue extracts and MCF7 (C), HeLa (D), Jurkat (E) and NIH/3T3 (F) whole cell lysates.

HBXIP (FL-91) - sc-134791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HBXIP (FL-91): sc-134791. Western blot analysis of HBXIP expression in non-transfected: sc-117752 (A) and human HBXIP transfected: sc-116745 (B) 293T whole cell lysates.

HBXIP (N-14) - sc-54081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HBXIP (N-14): sc-54081. Western blot analysis of HBXIP expression in non-transfected: sc-117752 (A) and human HBXIP transfected: sc-116745 (B) 293T whole cell lysates.

HBXIP (S-15) - sc-54082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HBXIP (S-15): sc-54082. Western blot analysis of HBXIP expression in non-transfected: sc-117752 (A) and human HBXIP transfected: sc-116745 (B) 293T whole cell lysates.

HBXIP (T-17) - sc-54083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HBXIP antibody - ab66258 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-HBXIP antibody - ab125410 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HBXIP antibody (ab125410) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-HBXIP antibody [EPR11531(B)] - ab157480 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11531(B)
All lanes : Anti-HBXIP antibody [EPR11531(B)] (ab157480) at 1/1000 dilutionLane 1 : BxPC-3 cell lysateLane 2 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-HBXIP Antibody (N-Terminus) - LS-C111379 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HBXIP antibody LS-C111379 Western blot of Transfected 293T cell lysate.

Anti-HBXIP Antibody - LS-C310573 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HBXIP Antibody - NBP1-82664 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: HBXIP Antibody [NBP1-82664] Staining of human cell line A-431 shows positivity in cytoplasm.

HBXIP Antibody - NBP1-53103 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HBXIP Antibody [NBP1-53103] - Transfected 293T cell lysate, concentration 0.2-1 ug/ml.

HBXIP Antibody (3D3) - H00010542-M02A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3D3

HBXIP Antibody (4G1) - H00010542-M12 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G1

HBXIP Antibody - H00010542-D02P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HBXIP Antibody [H00010542-D02P] - Analysis of HBXIP expression in transfected 293T cell line by HBXIP polyclonal antibody.Lane 1: HBXIP transfected lysate(18.20 KDa).Lane 2: Non-transfected lysate.

HBXIP Antibody - H00010542-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Rabbit Anti-T Beta 10 Polyclonal Antibody - bs-1088R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse small intestine tissue labeled with Anti-T-Beta-10 Polyclonal Antibody, Unconjugated (bs-1080R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

HBXIP Polyclonal Antibody - bs-6869R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human hepatitides tissue labeled with Anti HBXIP Polyclonal Antibody,Unconjugated (bs-6869R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
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