| Gene Symbol |
FBXO3
|
| Entrez Gene |
26273
|
| Alt Symbol |
FBA, FBX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 3
|
| Other Description |
F-box only protein 3|F-box protein FBX3
|
| Swissprots |
Q9UK99 B3KY16 Q9H0V2 D3DR05 Q9NUX2 Q86X90
|
| Accessions |
EAW68186 EAW68187 EAW68188 EAW68189 EAW68190 EAW68191 Q9UK99 AB209039 BAD92276 AF174595 AAF04516 AF176702 AAF03702 AK001943 BAA91991 AK123198 AK128454 BAG54678 AK300721 BAH13334 AK304866 BAG65604 AK316286 BAH14657 AL136625 CAB66560 AL832826 BC017107 BC039291 AAH39291 BC046110 AAH46110 BG716664 EU832324 ACE87581 EU832409 ACE86894 XM_011519980 XP_011518282 XM_011519981 XP_011518283 XM_011519982 XP_011518284 NM_012175 NP_036307 NM_033406 NP_208385
|
| Function |
Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation. {ECO:0000269|PubMed:18809579}.
|
| Subcellular Location |
Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
|
![Western Blot: FBXO3 Overexpression Lysate (Adult Normal) [NBL1-10629] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FBXO3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1166_FBXO3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10629-img0002.jpg)