DHRS4

Gene Symbol	DHRS4
Entrez Gene	10901
Alt Symbol	CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2
Species	Human
Gene Type	protein-coding
Description	dehydrogenase/reductase (SDR family) member 4
Other Description	NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase|NADPH-dependent retinol dehydrogenase/reductase|dehydrogenase/reductase (SDR family) member 4 like 2A|dehydrogenase/reductase SDR family member 4|peroxisomal short-chain alcohol dehydrogenase|short chain dehydrogenase/reductase family 25C member 2|short chain dehydrogenase/reductase family 25C, member 1|short chain dehydrogenase/reductase family 25C, member 2|short-chain dehydrogenase/reductase family member 4
Swissprots	Q9NV08 Q2LE81 B2RB10 Q20CR0 Q8TD03 Q6UWU3 E2QRL8 D3YTB8 Q9BTZ2 Q9H3N5 Q71UQ6 Q2LC19 Q6E0Y1 Q58IU4 O95162 B7WNS9
Accessions	Q9BTZ2 AA293161 AA639837 AB045131 BAB18775 AF044127 AAD02292 AF064256 AAQ13444 AK001870 BAA91953 AK301201 BAH13431 AK308436 AK314448 BAG37057 AY071856 AAL61824 AY358638 AAQ89001 AY616182 AAT70757 BC003019 AAH03019 BP366505 BQ030242 BU529016 CA438339 CD674505 DQ325464 ABC61320 DQ338571 ABC61321 DQ344810 ABD75823 XM_006720005 XP_006720068 XM_011536366 XP_011534668 NM_001282987 NP_001269916 NM_001282988 NP_001269917 NM_001282989 NP_001269918 NM_001282990 NP_001269919 NM_001282991 NP_001269920 NM_021004 NP_066284
Function	Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.
Subcellular Location	Peroxisome {ECO:0000269|PubMed:10333503}. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
Tissue Specificity	Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
Top Pathways	Peroxisome, Retinol metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DHRS4 cDNA clone(NM_021004.2) - CDFG003140 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 cDNA clone(NM_021004.2) - CDFG003141 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 ORF Clone(NM_021004.2) - CDCR306439 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 ORF Clone(NM_021004.2) - CDCR306440 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 ORF Clone(NM_021004.2) - CDCL161017 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 ORF Clone(NM_021004.2) - CDCL161018 from Creative Biomart Species Human Accession NM_021004.2

Human DHRS4 Gene ORF cDNA clone in cloning vector - HG16356-G from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16356-NF from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid - HG16356-UT from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG16356-ANR from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG16356-CF from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG16356-ANG from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG16356-NM from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG16356-CM from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG16356-CY from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-His tag - HG16356-NH from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG16356-ACG from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, C-His tag - HG16356-CH from Sino Biological Species Human

Human DHRS4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG16356-NY from Sino Biological Species Human

Human DHRS4 ORF Clone(NM_021004.2) - CDCR306439 from Creative biogene Species Human

Human DHRS4 ORF clone (NM_001282989.1) - CDCB157356 from Creative biogene Species Human

Human DHRS4 cDNA Clone(NM_021004.2) - CDFG003140 from Creative biogene Species Human

Human DHRS4 cDNA Clone(NM_021004.2) - CDFG003141 from Creative biogene Species Human

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