| Gene Symbol | DHRS4 |
|---|---|
| Entrez Gene | 10901 |
| Alt Symbol | CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dehydrogenase/reductase (SDR family) member 4 |
| Other Description | NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase|NADPH-dependent retinol dehydrogenase/reductase|dehydrogenase/reductase (SDR family) member 4 like 2A|dehydrogenase/reductase SDR family member 4|peroxisomal short-chain alcohol dehydrogenase|short chain dehydrogenase/reductase family 25C member 2|short chain dehydrogenase/reductase family 25C, member 1|short chain dehydrogenase/reductase family 25C, member 2|short-chain dehydrogenase/reductase family member 4 |
| Swissprots | Q9NV08 Q2LE81 B2RB10 Q20CR0 Q8TD03 Q6UWU3 E2QRL8 D3YTB8 Q9BTZ2 Q9H3N5 Q71UQ6 Q2LC19 Q6E0Y1 Q58IU4 O95162 B7WNS9 |
| Accessions | Q9BTZ2 AA293161 AA639837 AB045131 BAB18775 AF044127 AAD02292 AF064256 AAQ13444 AK001870 BAA91953 AK301201 BAH13431 AK308436 AK314448 BAG37057 AY071856 AAL61824 AY358638 AAQ89001 AY616182 AAT70757 BC003019 AAH03019 BP366505 BQ030242 BU529016 CA438339 CD674505 DQ325464 ABC61320 DQ338571 ABC61321 DQ344810 ABD75823 XM_006720005 XP_006720068 XM_011536366 XP_011534668 NM_001282987 NP_001269916 NM_001282988 NP_001269917 NM_001282989 NP_001269918 NM_001282990 NP_001269919 NM_001282991 NP_001269920 NM_021004 NP_066284 |
| Function | Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}. |
| Subcellular Location | Peroxisome {ECO:0000269|PubMed:10333503}. Note=Isoform 1 is peroxisomal, while isoform 4 is not. |
| Tissue Specificity | Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues. |
| Top Pathways | Peroxisome, Retinol metabolism |
DHRS4 CRISPR/Cas9 KO Plasmid (h) - sc-411534 from Santa Cruz Biotechnology
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DHRS4 HDR Plasmid (h) - sc-411534-HDR from Santa Cruz Biotechnology
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DHRS4 Double Nickase Plasmid (h) - sc-411534-NIC from Santa Cruz Biotechnology
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DHRS4 Double Nickase Plasmid (h2) - sc-411534-NIC-2 from Santa Cruz Biotechnology
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DHRS4 CRISPR Activation Plasmid (h) - sc-411534-ACT from Santa Cruz Biotechnology
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DHRS4 CRISPR Activation Plasmid (h2) - sc-411534-ACT-2 from Santa Cruz Biotechnology
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DHRS4 Lentiviral Activation Particles (h) - sc-411534-LAC from Santa Cruz Biotechnology
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DHRS4 Lentiviral Activation Particles (h2) - sc-411534-LAC-2 from Santa Cruz Biotechnology
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DHRS4 siRNA (h) - sc-92193 from Santa Cruz Biotechnology
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DHRS4 shRNA Plasmid (h) - sc-92193-SH from Santa Cruz Biotechnology
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DHRS4 shRNA (h) Lentiviral Particles - sc-92193-V from Santa Cruz Biotechnology
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DHRS4 RNAi - H00010901-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7203 from Sigma-Aldrich
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DHRS4 siRNA (Human) - CRH7430 from Cohesion Biosciences
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DHRS4 - MBS8219426 from MyBioSource
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shRNA set against Human DHRS4 (NM_021004.2) - SHH277725 from Creative biogene
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shRNA set against Human DHRS4(NM_021004.2) - SHH004061 from Creative biogene
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Human DHRS4 siRNA - orb267932 from Biorbyt
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DHRS4 shRNA Plasmid (Human) - CHH7430 from Cohesion Biosciences
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DHRS4 miRNA 3'UTR clone - MiUTR1H-02813 from Creative biogene
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