Gene Symbol |
GSTO1
|
Entrez Gene |
9446
|
Alt Symbol |
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
glutathione S-transferase omega 1
|
Other Description |
MMA(V) reductase|S-(Phenacyl)glutathione reductase|epididymis secretory protein Li 21|glutathione S-transferase omega 1-1|glutathione S-transferase omega-1|glutathione-S-transferase like|glutathione-dependent dehydroascorbate reductase|monomethylarsonic acid reductase
|
Swissprots |
F5H7H0 P78417 Q5TA03 Q7Z3T2 D3DRA3
|
Accessions |
AAV68046 EAW49601 EAW49602 EAW49603 EAW49604 P78417 AF212303 AAF73376 AK313680 BAG36430 BC000127 AAH00127 BX537431 CAD97673 CA431506 CF130513 CN283947 DB501888 DT220068 EU794619 ACJ13673 U90313 AAB70109 NM_001191002 NP_001177931 NM_001191003 NP_001177932 NM_004832 NP_004823
|
Function |
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.
|
Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:11511179}.
|
Tissue Specificity |
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269|PubMed:10783391}.
|
Top Pathways |
Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450
|