Gene Symbol | GSTO1 |
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Entrez Gene | 9446 |
Alt Symbol | GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R |
Species | Human |
Gene Type | protein-coding |
Description | glutathione S-transferase omega 1 |
Other Description | MMA(V) reductase|S-(Phenacyl)glutathione reductase|epididymis secretory protein Li 21|glutathione S-transferase omega 1-1|glutathione S-transferase omega-1|glutathione-S-transferase like|glutathione-dependent dehydroascorbate reductase|monomethylarsonic acid reductase |
Swissprots | F5H7H0 P78417 Q5TA03 Q7Z3T2 D3DRA3 |
Accessions | AAV68046 EAW49601 EAW49602 EAW49603 EAW49604 P78417 AF212303 AAF73376 AK313680 BAG36430 BC000127 AAH00127 BX537431 CAD97673 CA431506 CF130513 CN283947 DB501888 DT220068 EU794619 ACJ13673 U90313 AAB70109 NM_001191002 NP_001177931 NM_001191003 NP_001177932 NM_004832 NP_004823 |
Function | Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:11511179}. |
Tissue Specificity | Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269|PubMed:10783391}. |
Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |
GSTO1 CRISPR/Cas9 KO Plasmid (h) - sc-404107 from Santa Cruz Biotechnology
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GSTO1 HDR Plasmid (h) - sc-404107-HDR from Santa Cruz Biotechnology
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GSTO1 Double Nickase Plasmid (h) - sc-404107-NIC from Santa Cruz Biotechnology
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GSTO1 Double Nickase Plasmid (h2) - sc-404107-NIC-2 from Santa Cruz Biotechnology
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GSTO1 CRISPR Activation Plasmid (h) - sc-404107-ACT from Santa Cruz Biotechnology
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GSTO1 CRISPR Activation Plasmid (h2) - sc-404107-ACT-2 from Santa Cruz Biotechnology
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GSTO1 Lentiviral Activation Particles (h) - sc-404107-LAC from Santa Cruz Biotechnology
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GSTO1 Lentiviral Activation Particles (h2) - sc-404107-LAC-2 from Santa Cruz Biotechnology
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GSTO1 siRNA (h) - sc-75207 from Santa Cruz Biotechnology
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GSTO1 shRNA Plasmid (h) - sc-75207-SH from Santa Cruz Biotechnology
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GSTO1 shRNA (h) Lentiviral Particles - sc-75207-V from Santa Cruz Biotechnology
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GSTO1 RNAi - H00009446-R01 from Novus Biologicals
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MISSION® esiRNA - EHU106471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9743 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9743 from Sigma-Aldrich
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GSTO1 siRNA (Human) - CRH6265 from Cohesion Biosciences
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GSTO1 - MBS8205425 from MyBioSource
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shRNA set against Human GSTO1 (NM_004832.2) - SHH308682 from Creative biogene
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Human GSTO1 siRNA - orb266767 from Biorbyt
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GSTO1 shRNA Plasmid (Human) - CHH6265 from Cohesion Biosciences
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GSTO1 miRNA 3'UTR clone - MiUTR3H-07720 from Creative biogene
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