| Gene Symbol |
EXOSC6
|
| Entrez Gene |
118460
|
| Alt Symbol |
EAP4, MTR3, Mtr3p, hMtr3p, p11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exosome component 6
|
| Other Description |
Mtr3 (mRNA transport regulator 3)-homolog|exosome complex component MTR3|exosome complex exonuclease MTR3|hMtr3|homolog of yeast mRNA transport regulator 3|mRNA transport regulator 3 homolog
|
| Swissprots |
Q5RKV6
|
| Accessions |
EAW51841 Q5RKV6 AK024276 AK095542 BC052252 AAH52252 NM_058219 NP_478126
|
| Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Nucleus {ECO:0000305}.
|
| Top Pathways |
RNA degradation
|