EXOSC6

Gene Symbol	EXOSC6
Entrez Gene	118460
Alt Symbol	EAP4, MTR3, Mtr3p, hMtr3p, p11
Species	Human
Gene Type	protein-coding
Description	exosome component 6
Other Description	Mtr3 (mRNA transport regulator 3)-homolog|exosome complex component MTR3|exosome complex exonuclease MTR3|hMtr3|homolog of yeast mRNA transport regulator 3|mRNA transport regulator 3 homolog
Swissprots	Q5RKV6
Accessions	EAW51841 Q5RKV6 AK024276 AK095542 BC052252 AAH52252 NM_058219 NP_478126
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Nucleus {ECO:0000305}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EXOSC6 (D-10) - sc-398277 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EXOSC6 (G-13) - sc-107534 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EXOSC6 (N-13) - sc-107536 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-EXOSC6 antibody - ab50910 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 antibody - N-terminal - ab138764 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, AP) - LS-C235097 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, APC) - LS-C235098 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (N-Terminus) - LS-C30332 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, Biotin) - LS-C235099 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, PE) - LS-C235101 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, FITC) - LS-C235100 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38, Azide-free, HRP) - LS-C249943 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38) - LS-C329521 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (N-Terminus) - LS-C30677 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EXOSC6 Antibody (aa12-38) - LS-C159579 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Exosome component 6 Antibody - NBP1-57508 from Novus Biologicals Prices $139.00, $299.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

Exosome component 6 Antibody - NBP1-57471 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 (AB2) antibody produced in rabbit - AV41087 from Sigma-Aldrich Prices $267.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EXOSC6 (AB1) antibody produced in rabbit - AV41086 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

P11 Antibody (OAAD00445) - OAAD00445 from Aviva Systems Biology Prices $290.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E7E10

EXOSC6 antibody - N-terminal region (ARP41086_P050) - ARP41086_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

EXOSC6 antibody - N-terminal region (ARP41087_T100) - ARP41087_T100 from Aviva Systems Biology Prices $229.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

EXOSC6-Antibody-N-term - AP19066a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

EXOSC6 antibody, N-term - GTX47229 from GeneTex Prices $319.00 Sizes 100 μg Host Rabbit Clonality Polyclonal

EXOSC6 antibody, N-term - GTX47230 from GeneTex Prices $319.00 Sizes 50 μg Host Rabbit Clonality Polyclonal

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