EXOSC6

Gene Symbol	EXOSC6
Entrez Gene	118460
Alt Symbol	EAP4, MTR3, Mtr3p, hMtr3p, p11
Species	Human
Gene Type	protein-coding
Description	exosome component 6
Other Description	Mtr3 (mRNA transport regulator 3)-homolog|exosome complex component MTR3|exosome complex exonuclease MTR3|hMtr3|homolog of yeast mRNA transport regulator 3|mRNA transport regulator 3 homolog
Swissprots	Q5RKV6
Accessions	EAW51841 Q5RKV6 AK024276 AK095542 BC052252 AAH52252 NM_058219 NP_478126
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Nucleus {ECO:0000305}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC6 protein fragment - ab165141 from Abcam Category Protein Source Wheat germ Species Human

EXOSC6 Antibody Blocking Peptide - LS-E6361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC6 Antibody Blocking Peptide - LS-E15082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC6 Antibody Blocking Peptide - LS-E15081 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Exosome component 6 Protein - H00118460-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EXOSC6-Antibody-N-term-Blocking-Peptide - BP19066a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC6 Blocking Peptide - 33R-5560 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC6 Blocking Peptide - 33R-6278 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC6 / MTR3 - H00118460-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EXOSC6 / MTR3 - H00118460-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Exosome complex component MTR3(EXOSC6) - CSB-YP722491HU CSB-EP722491HU CSB-BP722491HU CSB-MP722491HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC6 Peptide, Human - M34GP05146H from Creative Peptides Category Peptide Source Synthetic. Species Human

Exosome complex component MTR3 (EXOSC6), Recombinant Protein - MBS1293727 from MyBioSource Category Protein Prices $1,025.00, $1,025.00, $1,255.00, $1,255.00, $1,585.00, $1,585.00, $2,045.00, $2,045.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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