EXOSC6

Gene Symbol EXOSC6
Entrez Gene 118460
Alt Symbol EAP4, MTR3, Mtr3p, hMtr3p, p11
Species Human
Gene Type protein-coding
Description exosome component 6
Other Description Mtr3 (mRNA transport regulator 3)-homolog|exosome complex component MTR3|exosome complex exonuclease MTR3|hMtr3|homolog of yeast mRNA transport regulator 3|mRNA transport regulator 3 homolog
Swissprots Q5RKV6
Accessions EAW51841 Q5RKV6 AK024276 AK095542 BC052252 AAH52252 NM_058219 NP_478126
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Cytoplasm {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Nucleus {ECO:0000305}.
Top Pathways RNA degradation

EXOSC6 CRISPR/Cas9 KO Plasmid (h) - sc-405680 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 HDR Plasmid (h) - sc-405680-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 Double Nickase Plasmid (h) - sc-405680-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 Double Nickase Plasmid (h2) - sc-405680-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 CRISPR Activation Plasmid (h) - sc-405680-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 CRISPR Activation Plasmid (h2) - sc-405680-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 Lentiviral Activation Particles (h) - sc-405680-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 Lentiviral Activation Particles (h2) - sc-405680-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC6 siRNA (h) - sc-93448 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC6 shRNA Plasmid (h) - sc-93448-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC6 shRNA (h) Lentiviral Particles - sc-93448-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exosome component 6 RNAi - H00118460-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8051 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8051 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EXOSC6 siRNA (Human) - CRJ4584 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXOSC6 - MBS8241321 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EXOSC6 (NM_058219.2) - SHH288141 from Creative biogene

Category siRNA
Species Reactivities Human

EXOSC6 shRNA Plasmid (Human) - CHJ4584 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXOSC6 miRNA 3'UTR clone - MiUTR1H-03349 from Creative biogene

Species Reactivities Human
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