| Gene Symbol |
PTGS2
|
| Entrez Gene |
5743
|
| Alt Symbol |
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
|
| Other Description |
PGH synthase 2|PHS II|cyclooxygenase 2b|prostaglandin G/H synthase 2|prostaglandin H2 synthase 2
|
| Swissprots |
Q16876 P35354 A8K802
|
| Accessions |
AAA57317 AAD14842 AAF85977 AAN87129 AAO38056 AAQ75702 BAA05698 CBH19826 CBX54355 EAW91216 P35354 AJ634912 CAG25548 AK292167 BAF84856 AY151286 AAN52932 AY462100 AAR23927 BC013734 AAH13734 BM978796 DA277667 EU176282 ABW03733 EU176597 ABW03398 HM473188 ADJ56342 L15326 AAA35803 M90100 AAA58433 NM_000963 NP_000954
|
| Function |
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578}.
|
| Subcellular Location |
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
|
| Top Pathways |
Leishmaniasis, Chemical carcinogenesis, Retrograde endocannabinoid signaling, TNF signaling pathway, Ovarian steroidogenesis
|
